Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences
Monocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: “classical” (CD14++CD16-), “intermediate” (CD14++CD16+), and “nonclassical” (CD14+CD16++). Monocyte subsets play a pivotal role in many inflammatory systemic diseases...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/9782594 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560569773719552 |
|---|---|
| author | Noemi Cifani Maria Proietta Maurizio Taurino Luigi Tritapepe Flavia Del Porto |
| author_facet | Noemi Cifani Maria Proietta Maurizio Taurino Luigi Tritapepe Flavia Del Porto |
| author_sort | Noemi Cifani |
| collection | DOAJ |
| description | Monocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: “classical” (CD14++CD16-), “intermediate” (CD14++CD16+), and “nonclassical” (CD14+CD16++). Monocyte subsets play a pivotal role in many inflammatory systemic diseases including atherosclerosis (ATS). Only a low number of studies evaluated monocyte behavior in patients affected by cardiovascular diseases, and data about their role in acute aortic dissection (AAD) are lacking. Thus, the aim of this study was to investigate CD14++CD16-, CD14++CD16+, and CD14+CD16++ cells in patients with Stanford-A AAD and in patients with carotid artery stenosis (CAS). Methods. 20 patients with carotid artery stenosis (CAS group), 17 patients with Stanford-A AAD (AAD group), and 17 subjects with traditional cardiovascular risk factors (RF group) were enrolled. Monocyte subset frequency was determined by flow cytometry. Results. Classical monocytes were significantly increased in the AAD group versus CAS and RF groups, whereas intermediate monocytes were significantly decreased in the AAD group versus CAS and RF groups. Conclusions. Results of this study identify in AAD patients a peculiar monocyte array that can partly explain depletion of T CD4+ lymphocyte subpopulations observed in patients affected by AAD. |
| format | Article |
| id | doaj-art-fc763fae463f47e588e42680b69b39d7 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fc763fae463f47e588e42680b69b39d72025-02-03T01:27:17ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/97825949782594Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New EvidencesNoemi Cifani0Maria Proietta1Maurizio Taurino2Luigi Tritapepe3Flavia Del Porto4Dipartimento di Medicina Clinica e Molecolare, Ospedale Sant’Andrea, Facoltà di Medicina e Psicologia, Ospedale Sant’Andrea, “Sapienza, ” Università di Roma, ItalyDipartimento di Medicina Clinica e Molecolare, Ospedale Sant’Andrea, Facoltà di Medicina e Psicologia, Ospedale Sant’Andrea, UOS Aterosclerosi e Dislipidemia, “Sapienza, ” Università di Roma, ItalyDipartimento di Medicina Clinica e Molecolare, Ospedale Sant’Andrea, Facoltà di Medicina e Psicologia, Ospedale Sant’Andrea, UOC Chirurgia Vascolare, “Sapienza, ” Università di Roma, ItalyDipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Facoltà di Medicina e Odontoiatria, Policlinico Umberto I, “Sapienza, ” Università di Roma, ItalyDipartimento di Medicina Clinica e Molecolare, Ospedale Sant’Andrea, Facoltà di Medicina e Psicologia, Ospedale Sant’Andrea, UOC Medicina Interna, “Sapienza, ” Università di Roma, ItalyMonocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: “classical” (CD14++CD16-), “intermediate” (CD14++CD16+), and “nonclassical” (CD14+CD16++). Monocyte subsets play a pivotal role in many inflammatory systemic diseases including atherosclerosis (ATS). Only a low number of studies evaluated monocyte behavior in patients affected by cardiovascular diseases, and data about their role in acute aortic dissection (AAD) are lacking. Thus, the aim of this study was to investigate CD14++CD16-, CD14++CD16+, and CD14+CD16++ cells in patients with Stanford-A AAD and in patients with carotid artery stenosis (CAS). Methods. 20 patients with carotid artery stenosis (CAS group), 17 patients with Stanford-A AAD (AAD group), and 17 subjects with traditional cardiovascular risk factors (RF group) were enrolled. Monocyte subset frequency was determined by flow cytometry. Results. Classical monocytes were significantly increased in the AAD group versus CAS and RF groups, whereas intermediate monocytes were significantly decreased in the AAD group versus CAS and RF groups. Conclusions. Results of this study identify in AAD patients a peculiar monocyte array that can partly explain depletion of T CD4+ lymphocyte subpopulations observed in patients affected by AAD.http://dx.doi.org/10.1155/2019/9782594 |
| spellingShingle | Noemi Cifani Maria Proietta Maurizio Taurino Luigi Tritapepe Flavia Del Porto Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences Journal of Immunology Research |
| title | Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences |
| title_full | Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences |
| title_fullStr | Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences |
| title_full_unstemmed | Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences |
| title_short | Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences |
| title_sort | monocyte subsets stanford a acute aortic dissection and carotid artery stenosis new evidences |
| url | http://dx.doi.org/10.1155/2019/9782594 |
| work_keys_str_mv | AT noemicifani monocytesubsetsstanfordaacuteaorticdissectionandcarotidarterystenosisnewevidences AT mariaproietta monocytesubsetsstanfordaacuteaorticdissectionandcarotidarterystenosisnewevidences AT mauriziotaurino monocytesubsetsstanfordaacuteaorticdissectionandcarotidarterystenosisnewevidences AT luigitritapepe monocytesubsetsstanfordaacuteaorticdissectionandcarotidarterystenosisnewevidences AT flaviadelporto monocytesubsetsstanfordaacuteaorticdissectionandcarotidarterystenosisnewevidences |