Sirtuins as multifunctional regulators: Role in the pathogenesis of metabolic, inflammatory and neurodegenerative diseases and the effect of physical activity on their activity

Sirtuins as multifunctional regulators: Role in the pathogenesis of metabolic, inflammatory and neurodegenerative diseases and the effect of physical activity on their activity

Sirtuins, a family of NAD+-dependent deacetylases and ADP-ribosyltransferases, regulate cellular homeostasis and adaptive responses to environmental changes. Comprising seven isoforms (SIRT1–SIRT7), these enzymes have diverse functions, including gene expression regulation, mitochondrial function, o...

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Main Authors: Wojciech Matuszyński, Maria Matuszyńska, Patrycja Nowicka, Karolina Jezierska, Weronika Kalinowska, Mateusz Gural
Format: Article
Language:English
Published: Nicolaus Copernicus University in Toruń 2025-06-01
Series:Quality in Sport
Subjects:
Exercise and sirtuins
Sirtuins
Multifunctional regulators
Physical activity
Oxidative stress
Mitochondrial function
Online Access:https://apcz.umk.pl/QS/article/view/60514
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