A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection.

A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection.

Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain the gold standard, but are impractical for high-throughput screening. In this st...

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Main Authors: Pehuén Pereyra Gerber, Lidia M Duncan, Edward Jd Greenwood, Sara Marelli, Adi Naamati, Ana Teixeira-Silva, Thomas Wm Crozier, Ildar Gabaev, Jun R Zhan, Thomas E Mulroney, Emily C Horner, Rainer Doffinger, Anne E Willis, James Ed Thaventhiran, Anna V Protasio, Nicholas J Matheson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010265&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010265&type=printable

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