Engineered celastrol liposomes with glycyrrhizic acid augment synergistic antitumor efficacy in breast cancer

Engineered celastrol liposomes with glycyrrhizic acid augment synergistic antitumor efficacy in breast cancer

Background/ObjectivesBreast cancer treatment remains challenged by the non-specific distribution and systemic toxicity of conventional chemotherapeutics. Celastrol (CEL), a natural compound with antitumor efficacy, faces clinical limitations due to its toxicity and poor solubility. Glycyrrhizic acid...

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Bibliographic Details
Main Authors: Wei Zhang, Jiping Li, Xiuli Gao, Likun Liu, Hong Liang, Liling Yue
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
celastrol
glycyrrhizic acid
liposomes
breast cancer
DNA damage
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1602585/full
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