Multi-functional role of apolipoprotein E in neurodegenerative diseases

Genetic diversity in the apolipoprotein E (ApoE) gene has been identified as the major susceptibility genetic risk factor for sporadic Alzheimer’s disease (SAD). Specifically, the ApoEε4 allele is a significant risk factor for SAD, while ApoEε2 allele provides protection compared to the more common...

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Bibliographic Details
Main Authors: Sadequl Islam, Arshad Noorani, Yang Sun, Makoto Michikawa, Kun Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Aging Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1535280/full
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