Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway

Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway

Abstract Due to the low response rate and severe side effects, the clinical efficacy of current immunotherapy for patients with colorectal cancer (CRC) remains unsatisfactory. Induction of immunogenic cell death (ICD) has been evidenced to be conducive to enhancing the survival benefit of immune che...

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Bibliographic Details
Main Authors: Wei Wang, Lijiang Zhou, Xinyu Zhang, Zheng Li
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biology Direct
Subjects:
Protein regulator of cytokinesis 1
Colorectal cancer
Immunogenic cell death
PD-L1
Wnt/β-catenin
Online Access:https://doi.org/10.1186/s13062-025-00685-0
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