Acute myeloid leukemia-derived extracellular vesicles induced DNA methylation changes responsible for inflammatory program in normal hematopoietic stem progenitor cells

Acute myeloid leukemia-derived extracellular vesicles induced DNA methylation changes responsible for inflammatory program in normal hematopoietic stem progenitor cells

IntroductionAcute Myeloid Leukemia (AML) cells communicate with surrounding normal cells, including hematopoietic stem progenitor cells (HSPCs), in the bone marrow, and modify their fate supporting tumor growth. This communication can be mediated by Extracellular Vesicles (EVs), small vectors carryi...

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Bibliographic Details
Main Authors: Daniela Lamorte, Giovanni Calice, Stefania Trino, Michele Santodirocco, Antonella Caivano, Luciana De Luca, Ilaria Laurenzana
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
extracellular vesicles
hematopoietic stem and progenitor cells
DNA methylation
differentially expressed genes
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569159/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569159/full

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