MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. MicroRNA-26b (Mir26b) might play a role in several MASH-related pathways. Therefore, we aimed to determine the role of Mir26b in MASH and its therapeutic pote...

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Main Authors: Linsey Peters, Leonida Rakateli, Rosanna Huchzermeier, Andrea Bonnin-Marquez, Sanne L Maas, Cheng Lin, Alexander Jans, Yana Geng, Alan Gorter, Marion Gijbels, Sander Rensen, Peter Olinga, Tim Hendrikx, Marcin Krawczyk, Malvina Brisbois, Joachim Jankowski, Kiril Bidzhekov, Christian Weber, Erik AL Biessen, Ronit Shiri-Sverdlov, Tom Houben, Yvonne Döring, Matthias Bartneck, Emiel van der Vorst
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
metabolic dysfunction-associated steatohepatitis
hepatic inflammation
microRNAs
lipid nanoparticles
Online Access:https://elifesciences.org/articles/97165
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https://elifesciences.org/articles/97165

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