Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region
We aim to investigate some of the pathogenetic mediators of the human echinococcosis and to obtain updated epidemiological findings on cases of echinococcosis in Calabria, Southern Italy. Echinococcosis diagnosis was based on imaging, serological investigations, and molecular assay. Indeed, real-tim...
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| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/4283672 |
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| author | Giovanni Matera Maria Teresa Loria Cinzia Peronace Tatiana Catanzariti Pio Settembre Aida Giancotti Angelo G. Lamberti Giorgio S. Barreca Luisa Galati Gessica Dodaro Maria Mazzitelli Alessio Strazzulla Carlo Torti Angela Quirino Maria Carla Liberto Alfredo Focà |
| author_facet | Giovanni Matera Maria Teresa Loria Cinzia Peronace Tatiana Catanzariti Pio Settembre Aida Giancotti Angelo G. Lamberti Giorgio S. Barreca Luisa Galati Gessica Dodaro Maria Mazzitelli Alessio Strazzulla Carlo Torti Angela Quirino Maria Carla Liberto Alfredo Focà |
| author_sort | Giovanni Matera |
| collection | DOAJ |
| description | We aim to investigate some of the pathogenetic mediators of the human echinococcosis and to obtain updated epidemiological findings on cases of echinococcosis in Calabria, Southern Italy. Echinococcosis diagnosis was based on imaging, serological investigations, and molecular assay. Indeed, real-time PCR indicated the presence of G2/G3 genotypes of Echinococcus granulosus complex. Regarding pathogenesis, a relevant novel tool of immune depression should be deemed the reduced level of serum MCP-1. Also, we found a previously unreported VEGF, possibly associated with neovascularization requested by the parasite cyst metabolism. Cytokine profiles suggest a bias of the immunity toward Th2 and Treg responses. Nitric oxide levels exhibited a significant decrease one week after therapy versus basal level measured before surgery and/or chemotherapy. An increase of serum total IgE class and IgG4 subclass was found in Echinococcus-positive patients versus controls. Our data demonstrated an endemic spreading, at least in the province of Catanzaro and neighboring Calabria territories, for such parasitosis with the novel issue of the number of female overcoming male cases. In conclusion, the novel findings of this study were the increased VEGF and the reduced serum MCP-1 in the studied cases, as well as the number of Echinococcus-infected females overcoming the infected males. |
| format | Article |
| id | doaj-art-fc02e84cf86843b88c4fd09f1d9465f4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fc02e84cf86843b88c4fd09f1d9465f42025-02-03T01:25:59ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/42836724283672Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria RegionGiovanni Matera0Maria Teresa Loria1Cinzia Peronace2Tatiana Catanzariti3Pio Settembre4Aida Giancotti5Angelo G. Lamberti6Giorgio S. Barreca7Luisa Galati8Gessica Dodaro9Maria Mazzitelli10Alessio Strazzulla11Carlo Torti12Angela Quirino13Maria Carla Liberto14Alfredo Focà15Institute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInfection Disease Unit, Department of Medical and Surgical Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInfection Disease Unit, Department of Medical and Surgical Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInfection Disease Unit, Department of Medical and Surgical Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInstitute of Microbiology, Department of Health Sciences, “Magna Græcia” University of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyWe aim to investigate some of the pathogenetic mediators of the human echinococcosis and to obtain updated epidemiological findings on cases of echinococcosis in Calabria, Southern Italy. Echinococcosis diagnosis was based on imaging, serological investigations, and molecular assay. Indeed, real-time PCR indicated the presence of G2/G3 genotypes of Echinococcus granulosus complex. Regarding pathogenesis, a relevant novel tool of immune depression should be deemed the reduced level of serum MCP-1. Also, we found a previously unreported VEGF, possibly associated with neovascularization requested by the parasite cyst metabolism. Cytokine profiles suggest a bias of the immunity toward Th2 and Treg responses. Nitric oxide levels exhibited a significant decrease one week after therapy versus basal level measured before surgery and/or chemotherapy. An increase of serum total IgE class and IgG4 subclass was found in Echinococcus-positive patients versus controls. Our data demonstrated an endemic spreading, at least in the province of Catanzaro and neighboring Calabria territories, for such parasitosis with the novel issue of the number of female overcoming male cases. In conclusion, the novel findings of this study were the increased VEGF and the reduced serum MCP-1 in the studied cases, as well as the number of Echinococcus-infected females overcoming the infected males.http://dx.doi.org/10.1155/2018/4283672 |
| spellingShingle | Giovanni Matera Maria Teresa Loria Cinzia Peronace Tatiana Catanzariti Pio Settembre Aida Giancotti Angelo G. Lamberti Giorgio S. Barreca Luisa Galati Gessica Dodaro Maria Mazzitelli Alessio Strazzulla Carlo Torti Angela Quirino Maria Carla Liberto Alfredo Focà Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region Mediators of Inflammation |
| title | Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region |
| title_full | Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region |
| title_fullStr | Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region |
| title_full_unstemmed | Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region |
| title_short | Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region |
| title_sort | increase of vascular endothelial growth factor and decrease of mcp 1 and some updated epidemiology aspects of cystic echinococcosis human cases in calabria region |
| url | http://dx.doi.org/10.1155/2018/4283672 |
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