Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway

Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway

Radiation-induced intestinal injury (RIII) is a significant concern for cancer patients receiving radiation therapy, as it can lead to complications such as radiation enteropathy. Presently, there are limited options for preventing or treating RIII. Tea polyphenols (TP), found in tea, provide variou...

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Bibliographic Details
Main Authors: Runtian Li, Lintao Li, Haiyang Wu, Hui Gan, Zhuona Wu, Ruolan Gu, Xiaoxia Zhu, Shuchen Liu, Zhiyun Meng, Guifang Dou
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
radiation-induced intestinal injury
tea polyphenol
ferroptosis
HSP90
gut microbiota
metabolites
Online Access:https://www.mdpi.com/2076-3921/14/5/580
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