Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial
Abstract Background Transoral laser microsurgery is widely used for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is commonly used in vocal cord augmentation. We investigated the impact of intra-operative injection laryngoplasty on voice outcomes in early glottic cancer. Methods Twenty patien...
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SAGE Publishing
2022-03-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-022-00564-y |
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| author | Ayham Al Afif Matthew H. Rigby Colin MacKay Timothy F. Brown Timothy J. Phillips Usman Khan Jonathan R. B. Trites Martin Corsten S. Mark Taylor |
| author_facet | Ayham Al Afif Matthew H. Rigby Colin MacKay Timothy F. Brown Timothy J. Phillips Usman Khan Jonathan R. B. Trites Martin Corsten S. Mark Taylor |
| author_sort | Ayham Al Afif |
| collection | DOAJ |
| description | Abstract Background Transoral laser microsurgery is widely used for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is commonly used in vocal cord augmentation. We investigated the impact of intra-operative injection laryngoplasty on voice outcomes in early glottic cancer. Methods Twenty patients were randomized to the treatment group receiving HA injection to the vocal cord contralateral to the lesion; or the control group, receiving no injection. Patients had a Voice Handicap Index-10 (VHI-10) questionnaire and a Maximum Phonation Time (MPT) measurement preoperatively and at 3, 12 and 24 months post-operatively. Mean change in VHI-10 and MPT, compared to baseline and between time points, were compared. Survival estimates were calculated. Results Mean VHI-10 scores improved over time amongst all patients. There were no changes in mean VHI-10 from pre-operative values to 3, 12 or 24 months post-operatively. There were no significant differences when comparing various timepoints between groups. There were no significant changes in MPT amongst the groups, or the time-points compared. Two-year overall survival was 91.7%; disease free survival was 80.9%; no difference in recurrence free survival was seen between the groups. Conclusion Subjective voice scores improved over time in both groups; there were no improvements in VHI-10 or MPT scores in the injection group, over control, at any time points. We saw no significant impact for intra-operative HA injection laryngoplasty on subjective or objective voice outcomes following surgery for early glottic cancers. Graphical abstract |
| format | Article |
| id | doaj-art-fbc2a31eb6d6498a8dda7b104059060d |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-fbc2a31eb6d6498a8dda7b104059060d2025-02-03T10:54:12ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162022-03-0151111010.1186/s40463-022-00564-yInjection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trialAyham Al Afif0Matthew H. Rigby1Colin MacKay2Timothy F. Brown3Timothy J. Phillips4Usman Khan5Jonathan R. B. Trites6Martin Corsten7S. Mark Taylor8Queen Elizabeth II Health Sciences CentreQueen Elizabeth II Health Sciences CentreQueen Elizabeth II Health Sciences CentreQueen Elizabeth II Health Sciences CentreDepartment of Surgery, Queen’s UniversityQueen Elizabeth II Health Sciences CentreQueen Elizabeth II Health Sciences CentreQueen Elizabeth II Health Sciences CentreQueen Elizabeth II Health Sciences CentreAbstract Background Transoral laser microsurgery is widely used for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is commonly used in vocal cord augmentation. We investigated the impact of intra-operative injection laryngoplasty on voice outcomes in early glottic cancer. Methods Twenty patients were randomized to the treatment group receiving HA injection to the vocal cord contralateral to the lesion; or the control group, receiving no injection. Patients had a Voice Handicap Index-10 (VHI-10) questionnaire and a Maximum Phonation Time (MPT) measurement preoperatively and at 3, 12 and 24 months post-operatively. Mean change in VHI-10 and MPT, compared to baseline and between time points, were compared. Survival estimates were calculated. Results Mean VHI-10 scores improved over time amongst all patients. There were no changes in mean VHI-10 from pre-operative values to 3, 12 or 24 months post-operatively. There were no significant differences when comparing various timepoints between groups. There were no significant changes in MPT amongst the groups, or the time-points compared. Two-year overall survival was 91.7%; disease free survival was 80.9%; no difference in recurrence free survival was seen between the groups. Conclusion Subjective voice scores improved over time in both groups; there were no improvements in VHI-10 or MPT scores in the injection group, over control, at any time points. We saw no significant impact for intra-operative HA injection laryngoplasty on subjective or objective voice outcomes following surgery for early glottic cancers. Graphical abstracthttps://doi.org/10.1186/s40463-022-00564-yEarly glottic cancerTransoral surgeryLaryngoplastyVoice outcomes |
| spellingShingle | Ayham Al Afif Matthew H. Rigby Colin MacKay Timothy F. Brown Timothy J. Phillips Usman Khan Jonathan R. B. Trites Martin Corsten S. Mark Taylor Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial Journal of Otolaryngology - Head and Neck Surgery Early glottic cancer Transoral surgery Laryngoplasty Voice outcomes |
| title | Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial |
| title_full | Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial |
| title_fullStr | Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial |
| title_full_unstemmed | Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial |
| title_short | Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial |
| title_sort | injection laryngoplasty during transoral laser microsurgery for early glottic cancer a randomized controlled trial |
| topic | Early glottic cancer Transoral surgery Laryngoplasty Voice outcomes |
| url | https://doi.org/10.1186/s40463-022-00564-y |
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