Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

Abstract Adenosine signaling is a crucial immunosuppressive pathway within the tumor microenvironment, making it a promising target for cancer therapy. In this study, it is demonstrated that Globo H ceramide (GHCer), the most prevalent tumor‐associated glycosphingolipid, influences the tumor microen...

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Main Authors: Jing‐Yan Cheng, Hsiu‐Hui Tsai, Jung‐Tung Hung, Tsai‐Hsien Hung, Chun‐Cheng Lin, Chien‐Wei Lee, Zi‐Chi Lo, Jing‐Rong Huang, Shih‐Pin Chiou, Yenlin Huang, Shih‐Hsiang Chen, Chun‐Nan Yeh, John Yu, Alice L. Yu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
Adenosine receptor 2A
Globo H ceramide
TRAX
Treg
Online Access:https://doi.org/10.1002/advs.202416501
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https://doi.org/10.1002/advs.202416501

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