Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/205761 |
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| _version_ | 1850161229083967488 |
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| author | Seong-Ho Koh Wonki Baek Seung H. Kim |
| author_facet | Seong-Ho Koh Wonki Baek Seung H. Kim |
| author_sort | Seong-Ho Koh |
| collection | DOAJ |
| description | Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy. |
| format | Article |
| id | doaj-art-fba636f28f0e4d67a97f9b3684c6d2d7 |
| institution | OA Journals |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-fba636f28f0e4d67a97f9b3684c6d2d72025-08-20T02:22:55ZengWileyNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/205761205761Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral SclerosisSeong-Ho Koh0Wonki Baek1Seung H. Kim2Department of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of KoreaDepartment of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of KoreaDepartment of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of KoreaGlycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.http://dx.doi.org/10.1155/2011/205761 |
| spellingShingle | Seong-Ho Koh Wonki Baek Seung H. Kim Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis Neurology Research International |
| title | Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis |
| title_full | Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis |
| title_fullStr | Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis |
| title_short | Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis |
| title_sort | brief review of the role of glycogen synthase kinase 3β in amyotrophic lateral sclerosis |
| url | http://dx.doi.org/10.1155/2011/205761 |
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