Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions
The Modulator of Apoptosis 1 (MOAP-1) protein, a crucial regulator of apoptosis, has recently attracted considerable interest in oncology research. Its potential as a therapeutic target in bladder, breast, and non-small cell lung cancer (NSCLC) offers intriguing new therapeutic approaches. This com...
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| Format: | Article |
| Language: | English |
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HH Publisher
2023-12-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/902 |
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| _version_ | 1832541450667032576 |
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| author | Xinwei Koong Keyun Look Amar Daud Iskandar Abdullah Kuan Onn Tan Vasudevan Mani Hooi-Leng Ser Khang Wen Goh Ali Saleh Alkhoshaiban Long Chiau Ming |
| author_facet | Xinwei Koong Keyun Look Amar Daud Iskandar Abdullah Kuan Onn Tan Vasudevan Mani Hooi-Leng Ser Khang Wen Goh Ali Saleh Alkhoshaiban Long Chiau Ming |
| author_sort | Xinwei Koong |
| collection | DOAJ |
| description |
The Modulator of Apoptosis 1 (MOAP-1) protein, a crucial regulator of apoptosis, has recently attracted considerable interest in oncology research. Its potential as a therapeutic target in bladder, breast, and non-small cell lung cancer (NSCLC) offers intriguing new therapeutic approaches. This comprehensive review consolidated work on MOAP-1's role in cancer biology, notably as a therapeutic target. A systematic review was conducted by searching digital databases for studies. Based on inclusion and exclusion criteria, ten articles were thoroughly assessed. Emerging evidence links MOAP-1 to bladder cancer chemosensitivity and MOAP-1-dependent chemosensitization of breast cancer mediated by phenylquinazoline derivatives. In addition, apoptosis in breast cancer cells was induced by α-mangostin, a potential therapeutic drug targeting MOAP-1 and BCL-XL interaction. Studies showed MOAP-1's importance in NSCLC, with its upregulation in the cancer cells as a potential treatment. This review also highlights the role of miR-25 as a cellular regulator of MOAP-1 and its implication for MOAP-1-mediated therapeutics. The intricate control of MOAP-1 in cancer highlights the need for more research to understand its function and regulation across cancer types completely. MOAP-1's tumor suppressor activity suggests it could be a therapeutic target, as evidenced by current research findings, which is likely to spur further research into MOAP-1-targeted cancer treatments. This systematic review fills a gap in the literature by bringing together a variety of study findings to promote a deeper understanding of MOAP-1 and its therapeutic potential.
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| format | Article |
| id | doaj-art-fb9df64d158e425fbaa4a100a7c0ae8a |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-fb9df64d158e425fbaa4a100a7c0ae8a2025-02-04T08:39:46ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492023-12-016110.36877/pmmb.a0000387Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future DirectionsXinwei KoongKeyun LookAmar Daud Iskandar AbdullahKuan Onn TanVasudevan ManiHooi-Leng SerKhang Wen GohAli Saleh AlkhoshaibanLong Chiau Ming The Modulator of Apoptosis 1 (MOAP-1) protein, a crucial regulator of apoptosis, has recently attracted considerable interest in oncology research. Its potential as a therapeutic target in bladder, breast, and non-small cell lung cancer (NSCLC) offers intriguing new therapeutic approaches. This comprehensive review consolidated work on MOAP-1's role in cancer biology, notably as a therapeutic target. A systematic review was conducted by searching digital databases for studies. Based on inclusion and exclusion criteria, ten articles were thoroughly assessed. Emerging evidence links MOAP-1 to bladder cancer chemosensitivity and MOAP-1-dependent chemosensitization of breast cancer mediated by phenylquinazoline derivatives. In addition, apoptosis in breast cancer cells was induced by α-mangostin, a potential therapeutic drug targeting MOAP-1 and BCL-XL interaction. Studies showed MOAP-1's importance in NSCLC, with its upregulation in the cancer cells as a potential treatment. This review also highlights the role of miR-25 as a cellular regulator of MOAP-1 and its implication for MOAP-1-mediated therapeutics. The intricate control of MOAP-1 in cancer highlights the need for more research to understand its function and regulation across cancer types completely. MOAP-1's tumor suppressor activity suggests it could be a therapeutic target, as evidenced by current research findings, which is likely to spur further research into MOAP-1-targeted cancer treatments. This systematic review fills a gap in the literature by bringing together a variety of study findings to promote a deeper understanding of MOAP-1 and its therapeutic potential. https://journals.hh-publisher.com/index.php/pmmb/article/view/902 |
| spellingShingle | Xinwei Koong Keyun Look Amar Daud Iskandar Abdullah Kuan Onn Tan Vasudevan Mani Hooi-Leng Ser Khang Wen Goh Ali Saleh Alkhoshaiban Long Chiau Ming Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions Progress in Microbes and Molecular Biology |
| title | Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions |
| title_full | Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions |
| title_fullStr | Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions |
| title_full_unstemmed | Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions |
| title_short | Therapeutic Targeting of MOAP-1 in Cancer: A Systematic Review of Current Approaches and Future Directions |
| title_sort | therapeutic targeting of moap 1 in cancer a systematic review of current approaches and future directions |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/902 |
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