Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis
AimThis study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease.Data synthesisData searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect,...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1522318/full |
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| author | Donna Pratiwi Miko Sidartha Elvan Wiyarta Elvan Wiyarta I Wayan Agustinus Harimawan Ni Made Dwi Asti Lestari Bonglee Kim Nurpudji Astuti Taslim Trina Ekawati Tallei Fahrul Nurkolis Rony Abdi Syahputra |
| author_facet | Donna Pratiwi Miko Sidartha Elvan Wiyarta Elvan Wiyarta I Wayan Agustinus Harimawan Ni Made Dwi Asti Lestari Bonglee Kim Nurpudji Astuti Taslim Trina Ekawati Tallei Fahrul Nurkolis Rony Abdi Syahputra |
| author_sort | Donna Pratiwi |
| collection | DOAJ |
| description | AimThis study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease.Data synthesisData searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect, ClinicalTrials.gov and NCBI. The search involved a combination of keywords related to genetics and obesity risk. Pooled Odds Ratio (POR) with 95% CI was calculated based on the pooled data. Review Manager (RevMan) 5.4.1 were used to analyze the data.ResultsFrom 18 studies, the results of the dominant genetic model AA vs. TT showed POR 95%Cl = 1.95 (1.36–2.80); p < 0.00001, in AA vs. TA genetic recessive model, POR 95%Cl =1.31 (1.07–1.60); p = 0.002, then the final model of TA vs. TT codominance genetic model obtained POR 95%Cl = 1.52 (1.04–2.23); p < 0.00001. The overall risk of bias was low.ConclusionFrom this research, it was found that there was a comparison of the genotype that had a higher risk of obesity, namely the AA genotype in multiethnic groups in Asia.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=546434. |
| format | Article |
| id | doaj-art-fb5eefd12ca04feeb35f5738a3b9eb8c |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-fb5eefd12ca04feeb35f5738a3b9eb8c2025-02-06T07:09:01ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15223181522318Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysisDonna Pratiwi0Miko Sidartha1Elvan Wiyarta2Elvan Wiyarta3I Wayan Agustinus Harimawan4Ni Made Dwi Asti Lestari5Bonglee Kim6Nurpudji Astuti Taslim7Trina Ekawati Tallei8Fahrul Nurkolis9Rony Abdi Syahputra10Department of Clinical Nutrition, Ternate Regional General Hospital, Ternate, IndonesiaDepartment of Internal Medicine, Bhayangkara Police Hospital Ternate, Ternate, IndonesiaCritical Care Department, University of Indonesia Hospital, Depok, IndonesiaService Department, Risetku, South Jakarta, Jakarta, IndonesiaDepartment of Clinical Nutrition, Prof.dr.I.G.N.G Ngoerah General Hospital, Bali, IndonesiaDepartment of Clinical Nutrition, Bali Mandara General Hospital, Bali, IndonesiaDepartment of Pathology, College of Korean Medicine, Kyung Hee Universitygu, Seoul, Republic of KoreaDepartment of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia0Department of Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, Indonesia1Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, IndonesiaAimThis study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease.Data synthesisData searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect, ClinicalTrials.gov and NCBI. The search involved a combination of keywords related to genetics and obesity risk. Pooled Odds Ratio (POR) with 95% CI was calculated based on the pooled data. Review Manager (RevMan) 5.4.1 were used to analyze the data.ResultsFrom 18 studies, the results of the dominant genetic model AA vs. TT showed POR 95%Cl = 1.95 (1.36–2.80); p < 0.00001, in AA vs. TA genetic recessive model, POR 95%Cl =1.31 (1.07–1.60); p = 0.002, then the final model of TA vs. TT codominance genetic model obtained POR 95%Cl = 1.52 (1.04–2.23); p < 0.00001. The overall risk of bias was low.ConclusionFrom this research, it was found that there was a comparison of the genotype that had a higher risk of obesity, namely the AA genotype in multiethnic groups in Asia.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=546434.https://www.frontiersin.org/articles/10.3389/fmed.2025.1522318/fullobesity riskFTO gene rs9939609Asiamultiethnic groupsAA genotype |
| spellingShingle | Donna Pratiwi Miko Sidartha Elvan Wiyarta Elvan Wiyarta I Wayan Agustinus Harimawan Ni Made Dwi Asti Lestari Bonglee Kim Nurpudji Astuti Taslim Trina Ekawati Tallei Fahrul Nurkolis Rony Abdi Syahputra Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis Frontiers in Medicine obesity risk FTO gene rs9939609 Asia multiethnic groups AA genotype |
| title | Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis |
| title_full | Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis |
| title_fullStr | Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis |
| title_full_unstemmed | Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis |
| title_short | Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis |
| title_sort | comparison of the risk of obesity in the fto rs9939609 genotype in a multiethnic group in asia systematic review and meta analysis |
| topic | obesity risk FTO gene rs9939609 Asia multiethnic groups AA genotype |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1522318/full |
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