A liquid chromatography-high-resolution mass spectrometry method for separation and identification of hemoglobin variant subunits with mass shifts less than 1 Da

Background: Identification of hemoglobin (Hb) variants is valuable in clinical testing. A common issue with conventional methods for identifying Hb variants is their subpar ability to provide structural breakdowns of the variants. Reports have surfaced of high-resolution mass spectrometry (HR-MS) me...

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Bibliographic Details
Main Authors: Ainslie Chen, Ryan M. Aquino, Hector A. Vidal, Carolyn V. Wong, Ruben Y. Luo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X25000021
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