Ribosomes: An Exciting Avenue in Stem Cell Research
Stem cell research has focused on genomic studies. However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. Ribosomes play a crucial role in epigenetic regulation, and thus, we focused on the role of ribosomes in stem cells. Majority of l...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8863539 |
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| author | Zhenzhen Han Qi Zhang Yanbo Zhu Jingcheng Chen Wei Li |
| author_facet | Zhenzhen Han Qi Zhang Yanbo Zhu Jingcheng Chen Wei Li |
| author_sort | Zhenzhen Han |
| collection | DOAJ |
| description | Stem cell research has focused on genomic studies. However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. Ribosomes play a crucial role in epigenetic regulation, and thus, we focused on the role of ribosomes in stem cells. Majority of living organisms possess ribosomes that are involved in the translation of mRNA into proteins and promote cellular proliferation and differentiation. Ribosomes are stable molecular machines that play a role with changes in the levels of RNA during translation. Recent research suggests that specific ribosomes actively regulate gene expression in multiple cell types, such as stem cells. Stem cells have the potential for self-renewal and differentiation into multiple lineages and, thus, require high efficiency of translation. Ribosomes induce cellular transdifferentiation and reprogramming, and disrupted ribosome synthesis affects translation efficiency, thereby hindering stem cell function leading to cell death and differentiation. Stem cell function is regulated by ribosome-mediated control of stem cell-specific gene expression. In this review, we have presented a detailed discourse on the characteristics of ribosomes in stem cells. Understanding ribosome biology in stem cells will provide insights into the regulation of stem cell function and cellular reprogramming. |
| format | Article |
| id | doaj-art-fb06a19751b8457db6fa6e49c768836e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-fb06a19751b8457db6fa6e49c768836e2025-02-03T01:05:01ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88635398863539Ribosomes: An Exciting Avenue in Stem Cell ResearchZhenzhen Han0Qi Zhang1Yanbo Zhu2Jingcheng Chen3Wei Li4Stem Cell and Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, ChinaStem Cell and Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, ChinaStem Cell and Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, ChinaStem Cell and Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, ChinaStem Cell and Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, ChinaStem cell research has focused on genomic studies. However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. Ribosomes play a crucial role in epigenetic regulation, and thus, we focused on the role of ribosomes in stem cells. Majority of living organisms possess ribosomes that are involved in the translation of mRNA into proteins and promote cellular proliferation and differentiation. Ribosomes are stable molecular machines that play a role with changes in the levels of RNA during translation. Recent research suggests that specific ribosomes actively regulate gene expression in multiple cell types, such as stem cells. Stem cells have the potential for self-renewal and differentiation into multiple lineages and, thus, require high efficiency of translation. Ribosomes induce cellular transdifferentiation and reprogramming, and disrupted ribosome synthesis affects translation efficiency, thereby hindering stem cell function leading to cell death and differentiation. Stem cell function is regulated by ribosome-mediated control of stem cell-specific gene expression. In this review, we have presented a detailed discourse on the characteristics of ribosomes in stem cells. Understanding ribosome biology in stem cells will provide insights into the regulation of stem cell function and cellular reprogramming.http://dx.doi.org/10.1155/2020/8863539 |
| spellingShingle | Zhenzhen Han Qi Zhang Yanbo Zhu Jingcheng Chen Wei Li Ribosomes: An Exciting Avenue in Stem Cell Research Stem Cells International |
| title | Ribosomes: An Exciting Avenue in Stem Cell Research |
| title_full | Ribosomes: An Exciting Avenue in Stem Cell Research |
| title_fullStr | Ribosomes: An Exciting Avenue in Stem Cell Research |
| title_full_unstemmed | Ribosomes: An Exciting Avenue in Stem Cell Research |
| title_short | Ribosomes: An Exciting Avenue in Stem Cell Research |
| title_sort | ribosomes an exciting avenue in stem cell research |
| url | http://dx.doi.org/10.1155/2020/8863539 |
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