Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project
Prostate cancer (PCa) stage at diagnosis is an important predictor of cancer prognosis. In Canada, over one-quarter of males are diagnosed with advanced-stage PCa. Studies have identified several factors associated with PCa stage at diagnosis; however, evidence from Canada is limited. This study aim...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2023/4426167 |
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| _version_ | 1832547959860887552 |
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| author | Michelle L. Aktary Brittany Shewchuk Qinggang Wang Eric Hyndman Lorraine Shack Paula J. Robson Karen A. Kopciuk |
| author_facet | Michelle L. Aktary Brittany Shewchuk Qinggang Wang Eric Hyndman Lorraine Shack Paula J. Robson Karen A. Kopciuk |
| author_sort | Michelle L. Aktary |
| collection | DOAJ |
| description | Prostate cancer (PCa) stage at diagnosis is an important predictor of cancer prognosis. In Canada, over one-quarter of males are diagnosed with advanced-stage PCa. Studies have identified several factors associated with PCa stage at diagnosis; however, evidence from Canada is limited. This study aimed to examine associations between sociodemographic characteristics, health history, health practices, and psychosocial factors and PCa stage at diagnosis among males participating in Alberta’s Tomorrow Project (ATP), a prospective cohort in Alberta, Canada. The study included males aged 35–69 years who developed PCa until January 2018. Factors associated with PCa stage at diagnosis were examined using partial proportional odds (PPO) ordinal regression models. A total of 410 males were diagnosed with PCa over the study period. A higher number of lifetime prostate-specific antigen tests were associated with earlier-stage PCa (OR 0.91, p = 0.02, 95% CI 0.83–0.99), while higher abdominal circumference (OR 1.02, p = 0.05, 95% CI 1.00–1.03), lower social support (OR 2.34, p < 0.01, 95% CI 1.31–4.17), and having children (OR 2.67, p < 0.01, 95% CI 1.38–5.16) were associated with later-stage disease. This study identified factors previously found in the literature as well as novel factors associated with PCa stage at diagnosis, which can help inform targets for cancer prevention programs to improve PCa prognosis. |
| format | Article |
| id | doaj-art-fae6994f464944579bfd68f3b8a610a7 |
| institution | Kabale University |
| issn | 2090-312X |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-fae6994f464944579bfd68f3b8a610a72025-02-03T06:42:54ZengWileyProstate Cancer2090-312X2023-01-01202310.1155/2023/4426167Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow ProjectMichelle L. Aktary0Brittany Shewchuk1Qinggang Wang2Eric Hyndman3Lorraine Shack4Paula J. Robson5Karen A. Kopciuk6Faculty of KinesiologyCancer Epidemiology and Prevention ResearchCancer Epidemiology and Prevention ResearchDepartment of SurgeryCancer Surveillance and ReportingDepartment of AgriculturalCancer Epidemiology and Prevention ResearchProstate cancer (PCa) stage at diagnosis is an important predictor of cancer prognosis. In Canada, over one-quarter of males are diagnosed with advanced-stage PCa. Studies have identified several factors associated with PCa stage at diagnosis; however, evidence from Canada is limited. This study aimed to examine associations between sociodemographic characteristics, health history, health practices, and psychosocial factors and PCa stage at diagnosis among males participating in Alberta’s Tomorrow Project (ATP), a prospective cohort in Alberta, Canada. The study included males aged 35–69 years who developed PCa until January 2018. Factors associated with PCa stage at diagnosis were examined using partial proportional odds (PPO) ordinal regression models. A total of 410 males were diagnosed with PCa over the study period. A higher number of lifetime prostate-specific antigen tests were associated with earlier-stage PCa (OR 0.91, p = 0.02, 95% CI 0.83–0.99), while higher abdominal circumference (OR 1.02, p = 0.05, 95% CI 1.00–1.03), lower social support (OR 2.34, p < 0.01, 95% CI 1.31–4.17), and having children (OR 2.67, p < 0.01, 95% CI 1.38–5.16) were associated with later-stage disease. This study identified factors previously found in the literature as well as novel factors associated with PCa stage at diagnosis, which can help inform targets for cancer prevention programs to improve PCa prognosis.http://dx.doi.org/10.1155/2023/4426167 |
| spellingShingle | Michelle L. Aktary Brittany Shewchuk Qinggang Wang Eric Hyndman Lorraine Shack Paula J. Robson Karen A. Kopciuk Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project Prostate Cancer |
| title | Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project |
| title_full | Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project |
| title_fullStr | Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project |
| title_full_unstemmed | Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project |
| title_short | Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project |
| title_sort | health related and psychosocial factors associated with prostate cancer stage at diagnosis among males participating in alberta s tomorrow project |
| url | http://dx.doi.org/10.1155/2023/4426167 |
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