Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling

Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling

Wound healing poses a considerable challenge in the domain of medical science. In modern clinical practice, there is a growing trend towards using herbal compounds to aid in the repair process. Among these, coumarin, a phytochemical recognized for its antibacterial and wound-healing properties, has...

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Main Authors: Eman F. Khaleel, Heba Abdelmegeed, Abdel-Razik H. Abdel-Razik, Manal S. Ebaid, Ninh The Son, Nguyen Xuan Ha, Hoda Atef Abdelsattar Ibrahim, Mohamed A. Abdelrahman, Abdelsamed I. Elshamy, Jarosław Dziadek, Ahmed Sabt, Wagdy M. Eldehna
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Chemistry
Subjects:
biological evaluation
in vivo study
TNF-α
inflammatory mediators
sulfonamides
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1621717/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1621717/full

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