Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers. The cancer-related function of cyclin D1 has been primarily studied by focusing on the phosphorylation...

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Bibliographic Details
Main Authors: Nelson García-Vázquez, Tania J González-Robles, Ethan Lane, Daria Spasskaya, Qingyue Zhang, Marc A Kerzhnerman, YeonTae Jeong, Marta Collu, Daniele Simoneschi, Kelly V Ruggles, Gergely Róna, Sharon Kaisari, Michele Pagano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
cyclin D1
CDK4
CDK6
cell proliferation
cullin-RING ligases
Online Access:https://elifesciences.org/articles/101075
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https://elifesciences.org/articles/101075

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