Increases in the susceptibility of human endometrial CD4+ T cells to HIV-1 infection post-menopause are not dependent on greater viral receptor expression frequency

Increases in the susceptibility of human endometrial CD4+ T cells to HIV-1 infection post-menopause are not dependent on greater viral receptor expression frequency

Epidemiological evidence suggests that post-menopausal women are more susceptible to HIV infection following sexual intercourse than are younger cohorts for reasons that remain unclear. Here, we evaluated how menopause-associated changes in CD4+ T cell numbers and subsets as well as HIV coreceptor e...

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Bibliographic Details
Main Authors: Landon G. vom Steeg, Zheng Shen, Jane Collins, Mickey V. Patel, Fiona D. Barr, Daniel C. Hopkins, Christina Ochsenbauer, Charles R. Wira
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
HIV-1
menopause
CD4+ T cells
macrophage
human female reproductive tract
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506653/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506653/full

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