Perampanel-associated Psychiatric Problems
Perampanel is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist used in the management of seizure disorder. Management of uncontrolled seizures is a challenging task. Perampanel is a recent antiepileptic which comes with a warning of causing behavior...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Archives of Medicine and Health Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/amhs.amhs_228_23 |
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| author | Anil Kakunje Shivanand Pai S. Raghavendra |
| author_facet | Anil Kakunje Shivanand Pai S. Raghavendra |
| author_sort | Anil Kakunje |
| collection | DOAJ |
| description | Perampanel is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist used in the management of seizure disorder. Management of uncontrolled seizures is a challenging task. Perampanel is a recent antiepileptic which comes with a warning of causing behavioral and psychological adverse effects. Here, the authors report an interesting case where the perampanel was started to control refractory seizures and the person developed severe behavioral disturbances. The condition warranted a psychiatry referral, and the problems subsided after stopping perampanel. Clinicians need to be vigilant about perampanel-associated behavioral and psychiatric problems which can become a serious clinical concern. |
| format | Article |
| id | doaj-art-fa657e8c0b43408a855773d2d7f865d3 |
| institution | Kabale University |
| issn | 2321-4848 2321-6085 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Archives of Medicine and Health Sciences |
| spelling | doaj-art-fa657e8c0b43408a855773d2d7f865d32025-01-23T08:51:45ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482321-60852024-01-0112111411510.4103/amhs.amhs_228_23Perampanel-associated Psychiatric ProblemsAnil KakunjeShivanand PaiS. RaghavendraPerampanel is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist used in the management of seizure disorder. Management of uncontrolled seizures is a challenging task. Perampanel is a recent antiepileptic which comes with a warning of causing behavioral and psychological adverse effects. Here, the authors report an interesting case where the perampanel was started to control refractory seizures and the person developed severe behavioral disturbances. The condition warranted a psychiatry referral, and the problems subsided after stopping perampanel. Clinicians need to be vigilant about perampanel-associated behavioral and psychiatric problems which can become a serious clinical concern.https://journals.lww.com/10.4103/amhs.amhs_228_23adverse effectperampanelpsychiatricseizure |
| spellingShingle | Anil Kakunje Shivanand Pai S. Raghavendra Perampanel-associated Psychiatric Problems Archives of Medicine and Health Sciences adverse effect perampanel psychiatric seizure |
| title | Perampanel-associated Psychiatric Problems |
| title_full | Perampanel-associated Psychiatric Problems |
| title_fullStr | Perampanel-associated Psychiatric Problems |
| title_full_unstemmed | Perampanel-associated Psychiatric Problems |
| title_short | Perampanel-associated Psychiatric Problems |
| title_sort | perampanel associated psychiatric problems |
| topic | adverse effect perampanel psychiatric seizure |
| url | https://journals.lww.com/10.4103/amhs.amhs_228_23 |
| work_keys_str_mv | AT anilkakunje perampanelassociatedpsychiatricproblems AT shivanandpai perampanelassociatedpsychiatricproblems AT sraghavendra perampanelassociatedpsychiatricproblems |