Bone marrow fluid enhances the osteogenic activity of induced membrane leading to spontaneous osteogenesis: experimental validation and application in tibiofibular fusion for support reconstruction of segmental tibial defects

Bone marrow fluid enhances the osteogenic activity of induced membrane leading to spontaneous osteogenesis: experimental validation and application in tibiofibular fusion for support reconstruction of segmental tibial defects

Abstract Background Managing large bone defects remains a significant clinical problem. We enhanced the osteogenic activity of the induced membrane (IM) by incorporating bone marrow fluid, leading to spontaneous osteogenesis (SO). We aimed to explore the application of this method in tibiofibular fu...

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Bibliographic Details
Main Authors: Qudong Yin, Xueming Chen, Shihao Du, Xuming Wei, Yongwei Wu, Fanyu Bu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Bone defect
Induced membrane
Tibiofibular fusion
Spontaneous osteogenesis
Bone marrow
Online Access:https://doi.org/10.1186/s12967-024-05840-1
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https://doi.org/10.1186/s12967-024-05840-1

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