Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

ABSTRACT Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26. At the animal level, zebrafish larvae with popdc3 mutat...

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Bibliographic Details
Main Authors: Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
mitochondrial dysfunction
POPDC3
protein homeostasis
skeletal muscle atrophy
skeletal muscle mass
Online Access:https://doi.org/10.1002/jcsm.13794
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https://doi.org/10.1002/jcsm.13794

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