Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases characterized by the clinical triad: tremor, akinesia, and rigidity. Several studies have suggested that PD patients show disturbances in olfaction as one of the earliest, nonspecific nonmotor symptoms of disease onset. We...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/3508073 |
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| author | Francescaelena De Rose Valentina Corda Paolo Solari Patrizia Sacchetti Antonio Belcari Simone Poddighe Sanjay Kasture Paolo Solla Francesco Marrosu Anna Liscia |
| author_facet | Francescaelena De Rose Valentina Corda Paolo Solari Patrizia Sacchetti Antonio Belcari Simone Poddighe Sanjay Kasture Paolo Solla Francesco Marrosu Anna Liscia |
| author_sort | Francescaelena De Rose |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is one of the most common neurodegenerative diseases characterized by the clinical triad: tremor, akinesia, and rigidity. Several studies have suggested that PD patients show disturbances in olfaction as one of the earliest, nonspecific nonmotor symptoms of disease onset. We sought to use the fruit fly Drosophila melanogaster as a model organism to explore olfactory function in LRRK loss-of-function mutants, which was previously demonstrated to be a useful model for PD. Surprisingly, our results showed that the LRRK mutant, compared to the wild flies, presents a dramatic increase in the amplitude of the electroantennogram responses and this is coupled with a higher number of olfactory sensilla. In spite of the above reported results, the behavioural response to olfactory stimuli in mutant flies is impaired compared to that obtained in wild type flies. Thus, behaviour modifications and morphofunctional changes in the olfaction of LRRK loss-of-function mutants might be used as an index to explore the progression of parkinsonism in this specific model, also with the aim of studying and developing new treatments. |
| format | Article |
| id | doaj-art-fa30a3e59e9e4c94a42d967f514a5fad |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-fa30a3e59e9e4c94a42d967f514a5fad2025-02-03T05:46:41ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/35080733508073Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional EvidencesFrancescaelena De Rose0Valentina Corda1Paolo Solari2Patrizia Sacchetti3Antonio Belcari4Simone Poddighe5Sanjay Kasture6Paolo Solla7Francesco Marrosu8Anna Liscia9Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyDepartment of Agricultural Biotechnology, Section of Plant Protection, University of Florence, Firenze, ItalyDepartment of Agricultural Biotechnology, Section of Plant Protection, University of Florence, Firenze, ItalyDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyPinnacle Biomedical Research Institute, Bhopal, IndiaDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, ItalyDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyParkinson’s disease (PD) is one of the most common neurodegenerative diseases characterized by the clinical triad: tremor, akinesia, and rigidity. Several studies have suggested that PD patients show disturbances in olfaction as one of the earliest, nonspecific nonmotor symptoms of disease onset. We sought to use the fruit fly Drosophila melanogaster as a model organism to explore olfactory function in LRRK loss-of-function mutants, which was previously demonstrated to be a useful model for PD. Surprisingly, our results showed that the LRRK mutant, compared to the wild flies, presents a dramatic increase in the amplitude of the electroantennogram responses and this is coupled with a higher number of olfactory sensilla. In spite of the above reported results, the behavioural response to olfactory stimuli in mutant flies is impaired compared to that obtained in wild type flies. Thus, behaviour modifications and morphofunctional changes in the olfaction of LRRK loss-of-function mutants might be used as an index to explore the progression of parkinsonism in this specific model, also with the aim of studying and developing new treatments.http://dx.doi.org/10.1155/2016/3508073 |
| spellingShingle | Francescaelena De Rose Valentina Corda Paolo Solari Patrizia Sacchetti Antonio Belcari Simone Poddighe Sanjay Kasture Paolo Solla Francesco Marrosu Anna Liscia Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences Parkinson's Disease |
| title | Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences |
| title_full | Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences |
| title_fullStr | Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences |
| title_full_unstemmed | Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences |
| title_short | Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences |
| title_sort | drosophila mutant model of parkinson s disease revealed an unexpected olfactory performance morphofunctional evidences |
| url | http://dx.doi.org/10.1155/2016/3508073 |
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