Fragile X messenger ribonucleoprotein 1 (FMRP) regulates glycolytic gene expression under chronic hypoxia in HCT116 cells

Fragile X messenger ribonucleoprotein 1 (FMRP) regulates glycolytic gene expression under chronic hypoxia in HCT116 cells

Abstract Oxygen shortage, known as hypoxia, occurs commonly in both physiological and pathological conditions. Transcriptional regulation by hypoxia-inducible factors is a dominant regulatory mechanism controlling hypoxia-responsive genes during acute hypoxia; however, recent studies suggest that po...

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Bibliographic Details
Main Authors: Yoko Ogura, Xiaoning Sun, Zaijun Zhang, Kentaro Kawata, Jinyu Wu, Ryuma Matsubara, Atsuko Nakanishi Ozeki, Kenzui Taniue, Rena Onoguchi-Mizutani, Shungo Adachi, Koh Nakayama, Nobuhito Goda, Nobuyoshi Akimitsu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Glycolysis
Hypoxia
Metabolic labeling
RNA degradation
RNA synthesis
Online Access:https://doi.org/10.1038/s41598-025-91828-w
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https://doi.org/10.1038/s41598-025-91828-w

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