Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours

Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours

Abstract Despite the current wealth of sequencing data, one‐third of all biochemically characterized metabolic enzymes lack a corresponding gene or protein sequence, and as such can be considered orphan enzymes. They represent a major gap between our molecular and biochemical knowledge, and conseque...

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Bibliographic Details
Main Authors: Takuji Yamada, Alison S Waller, Jeroen Raes, Aleksej Zelezniak, Nadia Perchat, Alain Perret, Marcel Salanoubat, Kiran R Patil, Jean Weissenbach, Peer Bork
Format: Article
Language:English
Published: Springer Nature 2012-05-01
Series:Molecular Systems Biology
Subjects:
genomics
metabolic pathways
metagenomics
neighbourhood information
orphan enzymes
Online Access:https://doi.org/10.1038/msb.2012.13
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https://doi.org/10.1038/msb.2012.13

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