Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials.

Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials.

<h4>Background</h4>People with comorbidities are underrepresented in clinical trials. Empirical estimates of treatment effect modification by comorbidity are lacking, leading to uncertainty in treatment recommendations. We aimed to produce estimates of treatment effect modification by co...

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Main Authors: Peter Hanlon, Elaine W Butterly, Anoop Sv Shah, Laurie J Hannigan, Jim Lewsey, Frances S Mair, David M Kent, Bruce Guthrie, Sarah H Wild, Nicky J Welton, Sofia Dias, David A McAllister
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004176&type=printable
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https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004176&type=printable

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