Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes

Abstract Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of syndromic ASD. It is unknown, however, w...

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Main Authors: Beata Stepniak, Anne Kästner, Giulia Poggi, Marina Mitjans, Martin Begemann, Annette Hartmann, Sandra Van der Auwera, Farahnaz Sananbenesi, Dilja Krueger‐Burg, Gabriela Matuszko, Cornelia Brosi, Georg Homuth, Henry Völzke, Fritz Benseler, Claudia Bagni, Utz Fischer, Alexander Dityatev, Hans‐Jörgen Grabe, Dan Rujescu, Andre Fischer, Hannelore Ehrenreich
Format: Article
Language:English
Published: Springer Nature 2015-11-01
Series:EMBO Molecular Medicine
Subjects:
FMR1
FMR2
FXR1
FXR2
miR‐181
PGAS
Online Access:https://doi.org/10.15252/emmm.201505696
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https://doi.org/10.15252/emmm.201505696

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