Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study
Objective: Endometrioid endometrial carcinomas (EEC) are the most commonly diagnosed malignancies of the female genital tract. Myometrial invasion depth is one of the most significant pathological prognostic parameters. Different morphological invasion patterns have been characterized. This study ai...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2022-09-01
|
| Series: | Medeniyet Medical Journal |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-40336 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832581998440349696 |
|---|---|
| author | Oguzhan OKCU Gokce ASKAN Bayram SEN Cigdem OZTURK Seda DUMAN OZTURK Gulname FINDIK GUVENDI |
| author_facet | Oguzhan OKCU Gokce ASKAN Bayram SEN Cigdem OZTURK Seda DUMAN OZTURK Gulname FINDIK GUVENDI |
| author_sort | Oguzhan OKCU |
| collection | DOAJ |
| description | Objective: Endometrioid endometrial carcinomas (EEC) are the most commonly diagnosed malignancies of the female genital tract. Myometrial invasion depth is one of the most significant pathological prognostic parameters. Different morphological invasion patterns have been characterized. This study aimed to investigate the prognostic significance of the microcystic elongated and fragmented (MELF) myometrium invasion pattern in patients with EEC and its relationship with other clinicopathological parameters.
Methods: This study included 101 patients with EEC in our institution between 2011 and 2020. The MELF pattern was evaluated in hematoxylin-eosin-stained sections. Pan-cytokeratin staining was performed on paraffin-embedded blocks of lymph nodes for cases without lymph node metastasis.
Results: The MELF pattern was observed in 29 (29.8%) patients. It was significantly associated with lymphovascular invasion (p<0.001), pathologic stage (p=0.048), infiltrative pattern (p<0.001), and necrosis (p=0.005). No significant correlation was observed between the MELF pattern and overall and disease-free survival rates.
Conclusions: The MELF pattern is associated with other prognostic parameters, but its prognostic significance for survival has not been found. If the MELF pattern is observed in the hysterectomy material for cases without lymph node dissection during the first surgery, these patients may need additional surgery or adjuvant therapy due to the high risk of lymphovascular invasion and lymph node metastasis. |
| format | Article |
| id | doaj-art-f9fa6c5696cc4b249eaad8ab29b1a426 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-f9fa6c5696cc4b249eaad8ab29b1a4262025-01-30T07:10:56ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062022-09-0137321221910.4274/MMJ.galenos.2022.40336MEDJ-40336Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective StudyOguzhan OKCU0Gokce ASKAN1Bayram SEN2Cigdem OZTURK3Seda DUMAN OZTURK4Gulname FINDIK GUVENDI5Recep Tayyip Erdogan University Training and Research Hospital, Clinic of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Clinic of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Clinic of Biochemistry, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Clinic of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Clinic of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Faculty of Medicine, Department of Pathology, Rize, TurkeyObjective: Endometrioid endometrial carcinomas (EEC) are the most commonly diagnosed malignancies of the female genital tract. Myometrial invasion depth is one of the most significant pathological prognostic parameters. Different morphological invasion patterns have been characterized. This study aimed to investigate the prognostic significance of the microcystic elongated and fragmented (MELF) myometrium invasion pattern in patients with EEC and its relationship with other clinicopathological parameters. Methods: This study included 101 patients with EEC in our institution between 2011 and 2020. The MELF pattern was evaluated in hematoxylin-eosin-stained sections. Pan-cytokeratin staining was performed on paraffin-embedded blocks of lymph nodes for cases without lymph node metastasis. Results: The MELF pattern was observed in 29 (29.8%) patients. It was significantly associated with lymphovascular invasion (p<0.001), pathologic stage (p=0.048), infiltrative pattern (p<0.001), and necrosis (p=0.005). No significant correlation was observed between the MELF pattern and overall and disease-free survival rates. Conclusions: The MELF pattern is associated with other prognostic parameters, but its prognostic significance for survival has not been found. If the MELF pattern is observed in the hysterectomy material for cases without lymph node dissection during the first surgery, these patients may need additional surgery or adjuvant therapy due to the high risk of lymphovascular invasion and lymph node metastasis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-40336microcystic elongated and fragmented (melf)endometrioid endometrial carcinomassurvival |
| spellingShingle | Oguzhan OKCU Gokce ASKAN Bayram SEN Cigdem OZTURK Seda DUMAN OZTURK Gulname FINDIK GUVENDI Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study Medeniyet Medical Journal microcystic elongated and fragmented (melf) endometrioid endometrial carcinomas survival |
| title | Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study |
| title_full | Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study |
| title_fullStr | Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study |
| title_full_unstemmed | Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study |
| title_short | Prognositc Significance of Microcystic Elongated and Fragmanted (MELF) Myometrial Invasion Pattern: A Retrospective Study |
| title_sort | prognositc significance of microcystic elongated and fragmanted melf myometrial invasion pattern a retrospective study |
| topic | microcystic elongated and fragmented (melf) endometrioid endometrial carcinomas survival |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-40336 |
| work_keys_str_mv | AT oguzhanokcu prognositcsignificanceofmicrocysticelongatedandfragmantedmelfmyometrialinvasionpatternaretrospectivestudy AT gokceaskan prognositcsignificanceofmicrocysticelongatedandfragmantedmelfmyometrialinvasionpatternaretrospectivestudy AT bayramsen prognositcsignificanceofmicrocysticelongatedandfragmantedmelfmyometrialinvasionpatternaretrospectivestudy AT cigdemozturk prognositcsignificanceofmicrocysticelongatedandfragmantedmelfmyometrialinvasionpatternaretrospectivestudy AT sedadumanozturk prognositcsignificanceofmicrocysticelongatedandfragmantedmelfmyometrialinvasionpatternaretrospectivestudy AT gulnamefindikguvendi prognositcsignificanceofmicrocysticelongatedandfragmantedmelfmyometrialinvasionpatternaretrospectivestudy |