Electroneuromyography for early diagnosis of diabetic distal polyneuropathy
BACKGROUND: Diabetic distal polyneuropathy (DDPN) is a predictor of diabetic foot syndrome development, ulcer formation and lower limb amputation. An early DDPN diagnosis is therefore relevant. AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diagn...
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Endocrinology Research Centre
2019-06-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/9830 |
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| author | Elena S. Mazurenko Lyudmila A. Ruyatkina Igor A. Pakhomov Elena V. Chesheva Larisa O. Gavrilova |
| author_facet | Elena S. Mazurenko Lyudmila A. Ruyatkina Igor A. Pakhomov Elena V. Chesheva Larisa O. Gavrilova |
| author_sort | Elena S. Mazurenko |
| collection | DOAJ |
| description | BACKGROUND: Diabetic distal polyneuropathy (DDPN) is a predictor of diabetic foot syndrome development, ulcer formation and lower limb amputation. An early DDPN diagnosis is therefore relevant. AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diagnosis. MATERIALS AND METHODS: This study was performed in the Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan. A total of 80 participants were examined, including 30 DM2 patients, 30 patents without carbohydrate metabolism disorders, and 20 healthy volunteers aged 20–30 years. None of the participants showed clinical signs of distal polyneuropathy (DPN). All participants underwent evaluation of neuropathy symptoms by the Neuropathy Symptom Score scale, neurological assessment using on the scale of Neuropathic Dysfunctional Score and stimulating ENMG. RESULTS: ENMG revealed the presence of neuropathy in 86.7% of DM2 patients. Moreover, among DM2 patients, 12 (40%) presented sensory DDPN, 13 (43.3%) presented sensorimotor neuropathy and 1 (3.3%) presented motor DDPN. The medial and lateral plantar nerves were the most commonly affected (p = 0.018 and p = 0.002, respectively). Among the 30 control individuals, 9 (30%) showed signs of DPN in combination with radiculopathy. ENMG - indicators of DDPN: latency and amplitude and speed for 3 sensory (n. Plantaris lateralis, n. Plantaris medialis, n. Suralis) and 2 motor nerves (n. Peroneus, n. Tibialis) were significantly worse in individuals with DM2 than in the control group, both for those with and without radiculopathy. Among participants with DM2, those sensorimotor DDPN tended to have a longer diabetes duration (p = 0.503), higher levels of HbA1c (p = 0.077) and higher BMI (p = 0.050) than those with sensory neuropathy, although the differences were not significant. CONCLUSION: This study confirms the effectiveness and suitability of ENMG for the early diagnosis of DDPN. Moreover, the optimal ENMG indices necessary for this diagnosis were identified. |
| format | Article |
| id | doaj-art-f9d71bd9da154f2fb6520711d8b3e0c7 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2019-06-01 |
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| series | Сахарный диабет |
| spelling | doaj-art-f9d71bd9da154f2fb6520711d8b3e0c72025-08-20T03:09:05ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782019-06-0122214115010.14341/DM98308708Electroneuromyography for early diagnosis of diabetic distal polyneuropathyElena S. Mazurenko0Lyudmila A. Ruyatkina1Igor A. Pakhomov2Elena V. Chesheva3Larisa O. Gavrilova4<p>Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan; Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences</p><p>Novosibirsk State Medical University</p><p>Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan</p><p>Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan</p><p>Innovative medical and technological center "Medical Technopark"</p>BACKGROUND: Diabetic distal polyneuropathy (DDPN) is a predictor of diabetic foot syndrome development, ulcer formation and lower limb amputation. An early DDPN diagnosis is therefore relevant. AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diagnosis. MATERIALS AND METHODS: This study was performed in the Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya. L. Tsivyan. A total of 80 participants were examined, including 30 DM2 patients, 30 patents without carbohydrate metabolism disorders, and 20 healthy volunteers aged 20–30 years. None of the participants showed clinical signs of distal polyneuropathy (DPN). All participants underwent evaluation of neuropathy symptoms by the Neuropathy Symptom Score scale, neurological assessment using on the scale of Neuropathic Dysfunctional Score and stimulating ENMG. RESULTS: ENMG revealed the presence of neuropathy in 86.7% of DM2 patients. Moreover, among DM2 patients, 12 (40%) presented sensory DDPN, 13 (43.3%) presented sensorimotor neuropathy and 1 (3.3%) presented motor DDPN. The medial and lateral plantar nerves were the most commonly affected (p = 0.018 and p = 0.002, respectively). Among the 30 control individuals, 9 (30%) showed signs of DPN in combination with radiculopathy. ENMG - indicators of DDPN: latency and amplitude and speed for 3 sensory (n. Plantaris lateralis, n. Plantaris medialis, n. Suralis) and 2 motor nerves (n. Peroneus, n. Tibialis) were significantly worse in individuals with DM2 than in the control group, both for those with and without radiculopathy. Among participants with DM2, those sensorimotor DDPN tended to have a longer diabetes duration (p = 0.503), higher levels of HbA1c (p = 0.077) and higher BMI (p = 0.050) than those with sensory neuropathy, although the differences were not significant. CONCLUSION: This study confirms the effectiveness and suitability of ENMG for the early diagnosis of DDPN. Moreover, the optimal ENMG indices necessary for this diagnosis were identified.https://www.dia-endojournals.ru/jour/article/view/9830diabetes mellitusdiabetic distal polyneuropathyelectroneuromyographydiagnosis |
| spellingShingle | Elena S. Mazurenko Lyudmila A. Ruyatkina Igor A. Pakhomov Elena V. Chesheva Larisa O. Gavrilova Electroneuromyography for early diagnosis of diabetic distal polyneuropathy Сахарный диабет diabetes mellitus diabetic distal polyneuropathy electroneuromyography diagnosis |
| title | Electroneuromyography for early diagnosis of diabetic distal polyneuropathy |
| title_full | Electroneuromyography for early diagnosis of diabetic distal polyneuropathy |
| title_fullStr | Electroneuromyography for early diagnosis of diabetic distal polyneuropathy |
| title_full_unstemmed | Electroneuromyography for early diagnosis of diabetic distal polyneuropathy |
| title_short | Electroneuromyography for early diagnosis of diabetic distal polyneuropathy |
| title_sort | electroneuromyography for early diagnosis of diabetic distal polyneuropathy |
| topic | diabetes mellitus diabetic distal polyneuropathy electroneuromyography diagnosis |
| url | https://www.dia-endojournals.ru/jour/article/view/9830 |
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