Murine HSD17β13 does not control liver steatosis and modestly impacts fibrosis in a sex- and diet-specific manner

Murine HSD17β13 does not control liver steatosis and modestly impacts fibrosis in a sex- and diet-specific manner

Human genetic studies show that loss of function mutations in 17-Beta hydroxysteroid dehydrogenase (HSD17β13) are associated with protection from non-alcoholic steatohepatitis (NASH). As a result, therapies that reduce HSD17β13 are being pursued for the treatment of NASH. However, inconsistent effec...

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Bibliographic Details
Main Authors: Justin D. Crane, Ornella Barrandon, Bryan Faherty, Matt Gorgoglione, Collin Crowley, Jeff Morin, Trenton T. Ross, Jackson Shimkonis, Dongmei Li, Dinesh Hirenallur-Shanthappa, Magalie Boucher, Youngwook Ahn, Michelle F. Clasquin
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Journal of Lipid Research
Subjects:
Live
lipids
triglycerides
enzymology
enzyme mechanisms
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524001391
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