Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist
The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The r...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000657 |
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| _version_ | 1832545826301280256 |
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| author | X. Nair G. Todderud L. Davern D. Lee A. Aruffo K. M. Tramposch |
| author_facet | X. Nair G. Todderud L. Davern D. Lee A. Aruffo K. M. Tramposch |
| author_sort | X. Nair |
| collection | DOAJ |
| description | The anti-inflammatory effect of a small molecular weight antagonist
of P- and E-selectin-dependent cell adhesion was examined. The
glycolipid sulphatide was shown to block the adherence of
thrombin-activated rat platelets to HL-60 cells. This interaction is
known to be dependent on P-selectin. The rat dermal reverse passive
Arthus reaction was used to assess the effect of sulphatide on a
neutrophil dependent inflammatory response. Sulphatide
dosedependently blocked both the vascular permeability increase and
cell infiltration after intraperitoneal administration. These
results show that a small molecular weight compound which blocks P-
and E-selectin dependent adhesion in vitro can
effectively block the inflammation due to immune complex deposition.
A compound with this type of profile may have therapeutic potential
in the treatment of immune complex mediated diseases. |
| format | Article |
| id | doaj-art-f9b43aa2b7424085b095a04bd32f6595 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f9b43aa2b7424085b095a04bd32f65952025-02-03T07:24:45ZengWileyMediators of Inflammation0962-93511466-18611994-01-013645946310.1155/S0962935194000657Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin AntagonistX. Nair0G. Todderud1L. Davern2D. Lee3A. Aruffo4K. M. Tramposch5Bristol-Myers Squibb Pharmaceutical Research Institute, 100 Forest Avenue, Buffalo 14213, NY, USABristol-Myers Squibb Pharmaceutical Research Institute, 100 Forest Avenue, Buffalo 14213, NY, USABristol-Myers Squibb Pharmaceutical Research Institute, 100 Forest Avenue, Buffalo 14213, NY, USABristol-Myers Squibb Pharmaceutical Research Institute, 100 Forest Avenue, Buffalo 14213, NY, USA3005 First Avenue, Seattle 98121, WA, USABristol-Myers Squibb Pharmaceutical Research Institute, 100 Forest Avenue, Buffalo 14213, NY, USAThe anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to immune complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of immune complex mediated diseases.http://dx.doi.org/10.1155/S0962935194000657 |
| spellingShingle | X. Nair G. Todderud L. Davern D. Lee A. Aruffo K. M. Tramposch Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist Mediators of Inflammation |
| title | Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist |
| title_full | Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist |
| title_fullStr | Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist |
| title_full_unstemmed | Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist |
| title_short | Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist |
| title_sort | inhibition of immune complex induced inflammation by a small molecular weight selectin antagonist |
| url | http://dx.doi.org/10.1155/S0962935194000657 |
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