Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist
The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The r...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000657 |
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| Summary: | The anti-inflammatory effect of a small molecular weight antagonist
of P- and E-selectin-dependent cell adhesion was examined. The
glycolipid sulphatide was shown to block the adherence of
thrombin-activated rat platelets to HL-60 cells. This interaction is
known to be dependent on P-selectin. The rat dermal reverse passive
Arthus reaction was used to assess the effect of sulphatide on a
neutrophil dependent inflammatory response. Sulphatide
dosedependently blocked both the vascular permeability increase and
cell infiltration after intraperitoneal administration. These
results show that a small molecular weight compound which blocks P-
and E-selectin dependent adhesion in vitro can
effectively block the inflammation due to immune complex deposition.
A compound with this type of profile may have therapeutic potential
in the treatment of immune complex mediated diseases. |
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| ISSN: | 0962-9351 1466-1861 |