Alternative splicing for tuneable expression of protein subunits at desired ratios

Alternative splicing for tuneable expression of protein subunits at desired ratios

The controlled expression of two or more proteins at a defined and stable ratio remains a substantial challenge, particularly in the bi- and multispecific antibody field. Achieving an optimal ratio of protein subunits can facilitate the assembly of multimeric proteins with high efficiency and minimi...

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Bibliographic Details
Main Authors: Christel Aebischer-Gumy, Pierre Moretti, Timothee Brunstein Laplace, Jana Frank, Ysaline Grand, Farid Mosbaoui, Emilie Hily, Anna Galea, Megane Peltret, Carole Estoppey, Daniel Ayoub, Roberto Giovannini, Martin Bertschinger
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
alternative splicing
bicistronic expression
tuneable subunit ratio
ratio optimization
controlled expression
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2342243
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https://www.tandfonline.com/doi/10.1080/19420862.2024.2342243

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