Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma

Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma

Abstract Clinical data have shown that Serine/Threonine Kinase 11 (STK11) mutation may be associated with an immunosuppressive tumor microenvironment (ITEM) and poor prognosis and failure of anti-PD-1 (αPD1) treatment in non-small cell lung cancer (NSCLC). To explore the potential of restoring STK11...

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Main Authors: Zhongquan Song, Qikai Wang, Hongjie Xiong, Jiang Xiao, Zihan Zhou, Tianxiang Li, Qian Sun, Liping Qiu, Yue Tan, Xiaohui Liu, Hui Jiang, Shuhua Han, Xuemei Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Lung adenocarcinoma
STK11 gene therapy
Anti-PD-1 treatment
Autophagy
Tumor immune microenvironment
Bionic drug delivery
Online Access:https://doi.org/10.1186/s12951-025-03404-z
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https://doi.org/10.1186/s12951-025-03404-z

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