Deletion of pagL and arnT genes involved in LPS structure and charge modulation in the Salmonella genome confer reduced endotoxicity and retained efficient protection against wild-type Salmonella Gallinarum challenge in chicken

Deletion of pagL and arnT genes involved in LPS structure and charge modulation in the Salmonella genome confer reduced endotoxicity and retained efficient protection against wild-type Salmonella Gallinarum challenge in chicken

Abstract Fowl typhoid (FT) poses a significant threat to the poultry industry and can cause substantial economic losses, especially in developing regions. Caused by Salmonella Gallinarum (SG), vaccination can prevent FT. However, existing vaccines, like the SG9R strain, have limitations, including r...

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Bibliographic Details
Main Authors: Ram Prasad Aganja, Jun Kwon, Amal Senevirathne, John Hwa Lee
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Veterinary Research
Subjects:
Fowl typhoid
Salmonella Gallinarum
genetic modification
lipopolysaccharide biosynthesis
vaccine
Online Access:https://doi.org/10.1186/s13567-024-01413-8
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https://doi.org/10.1186/s13567-024-01413-8

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