Dynamic neural network modulation associated with rumination in major depressive disorder: a prospective observational comparative analysis of cognitive behavioral therapy and pharmacotherapy

Dynamic neural network modulation associated with rumination in major depressive disorder: a prospective observational comparative analysis of cognitive behavioral therapy and pharmacotherapy

Abstract Cognitive behavioral therapy (CBT) and pharmacotherapy are primary treatments for major depressive disorder (MDD). However, their differential effects on the neural networks associated with rumination, or repetitive negative thinking, remain poorly understood. This study included 135 partic...

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Main Authors: Nariko Katayama, Kazushi Shinagawa, Jinichi Hirano, Yuki Kobayashi, Atsuo Nakagawa, Satoshi Umeda, Kei Kamiya, Miyuki Tajima, Mizuki Amano, Waka Nogami, Sakae Ihara, Sachiko Noda, Yuri Terasawa, Toshiaki Kikuchi, Masaru Mimura, Hiroyuki Uchida
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03489-y
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https://doi.org/10.1038/s41398-025-03489-y

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