IL-21 Modulates Release of Proinflammatory Cytokines in LPS-Stimulated Macrophages through Distinct Signaling Pathways

IL-21 Modulates Release of Proinflammatory Cytokines in LPS-Stimulated Macrophages through Distinct Signaling Pathways

The aim of this study was to investigate the anti-inflammatory effect of IL-21 on LPS-induced mouse peritoneal macrophages. The results showed that IL-21 significantly inhibited LPS-induced mRNA expression of IL-1β, TNF-α, and IL-6 in macrophages, but not of IFN-γ, IL-10, CCL5, or CXCL2. ELISA analy...

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Main Authors: Su-nan Li, Wei Wang, Shou-peng Fu, Jian-fa Wang, Hong-mei Liu, Shan-shan Xie, Bing-run Liu, Yang Li, Qing-kang Lv, Zhi-qiang Li, Wen-jing Xue, Bing-xu Huang, Wei Chen, Ju-xiong Liu
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/548073
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