Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets

Abstract Lysine lactylation (Kla) is a recently discovered post‑translational modification in which a lactyl moiety is transferred onto the ε‑amino group of lysine residues, linking cellular metabolism to epigenetic and signaling pathways. This process is regulated by a range of enzymes and metaboli...

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Bibliographic Details
Main Authors: Xia Peng, Juan Du
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Molecular Biomedicine
Subjects:
Online Access:https://doi.org/10.1186/s43556-025-00275-6
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