SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types

SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types

Recent advances in functional genomics tools have ushered in a new era of genetic editing to identify molecular pathways relevant to developmental and disease biology. However, limited model systems are available that adequately mimic cell states and phenotypes associated with human disease pathways...

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Bibliographic Details
Main Authors: Huinan Li, Maliha Afroze, Gunisha Arora, Scot Federman, Kaivalya Shevade, Yeqing Angela Yang, Phuong Nguyen, Rustam Esanov, Laralynne Przybyla, Adam Litterman, Shawn Shafer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Genetics
Subjects:
myeloid cell
microglia
macrophage
CRISPR
functional genomics
IPSC
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1574545/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1574545/full

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