Endosomal Trafficking Bypassed by the RAB5B‐CD109 Interplay Promotes Axonogenesis in KRAS‐Mutant Pancreatic Cancer

Endosomal Trafficking Bypassed by the RAB5B‐CD109 Interplay Promotes Axonogenesis in KRAS‐Mutant Pancreatic Cancer

Abstract Perineural invasion (PNI) represents a unique biological feature associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC), especially in the presence of KRAS mutations. Extracellular vesicle (EV)‐packaged circular RNAs (circRNAs) function as essential mediators of tumor mic...

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Bibliographic Details
Main Authors: Dingwen Zhang, Yuming Luo, Yan Lin, Zhou Fang, Hanhao Zheng, Mingjie An, Qingyu Xie, Zhuo Wu, Chao Yu, Jiabin Yang, Min Yu, Changhao Chen, Rufu Chen
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
circular RNA
engineered extracellular vesicle
KRAS mutation
pancreatic cancer
perineural invasion
Online Access:https://doi.org/10.1002/advs.202405092
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