Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics

Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics

Abstract Understanding complex biological systems requires tracing cellular dynamic changes across conditions, time, and space. However, integrating multi-sample data in a unified way to explore cellular heterogeneity remains challenging. Here, we present Stereopy, a flexible framework for modeling...

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Main Authors: Shuangsang Fang, Mengyang Xu, Lei Cao, Xiaobin Liu, Marija Bezulj, Liwei Tan, Zhiyuan Yuan, Yao Li, Tianyi Xia, Longyu Guo, Vladimir Kovacevic, Junhou Hui, Lidong Guo, Chao Liu, Mengnan Cheng, Li’ang Lin, Zhenbin Wen, Bojana Josic, Nikola Milicevic, Ping Qiu, Qin Lu, Yumei Li, Leying Wang, Luni Hu, Chao Zhang, Qiang Kang, Fengzhen Chen, Ziqing Deng, Junhua Li, Mei Li, Shengkang Li, Yi Zhao, Guangyi Fan, Yong Zhang, Ao Chen, Yuxiang Li, Xun Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58079-9
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https://doi.org/10.1038/s41467-025-58079-9

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