Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF
This study explores the impact of metformin dosage and hyperprolactinemia on galectin-3 levels in women with Polycystic Ovary Syndrome (PCOS), providing novel insights into their roles in the metabolic and hormonal management of the condition. A cohort of 53 women, diagnosed using the Rotterdam crit...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1505022/full |
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| author | Valentina N. Nikolić Milan Stefanović Milan Stefanović Dejan Mitić Dejan Mitić Slavica Sunarić Vladana Stojiljkovic Hristina Trajković Aleksandra Ignjatović Dragana Stokanović |
| author_facet | Valentina N. Nikolić Milan Stefanović Milan Stefanović Dejan Mitić Dejan Mitić Slavica Sunarić Vladana Stojiljkovic Hristina Trajković Aleksandra Ignjatović Dragana Stokanović |
| author_sort | Valentina N. Nikolić |
| collection | DOAJ |
| description | This study explores the impact of metformin dosage and hyperprolactinemia on galectin-3 levels in women with Polycystic Ovary Syndrome (PCOS), providing novel insights into their roles in the metabolic and hormonal management of the condition. A cohort of 53 women, diagnosed using the Rotterdam criteria and undergoing in vitro fertilization (IVF) preparation, was analyzed to determine how these factors influence galectin-3, a biomarker in PCOS. Using high-performance liquid chromatography to measure metformin concentrations and ELISA for galectin-3, our results revealed that both metformin dosage and hyperprolactinemia significantly statistically associated with galectin-3 levels, while body mass index (BMI) showed no significant association. These findings challenge prior assumptions and suggest that galectin-3 may be regulated via pathways independent of metformin pharmacokinetics. Notably, the correlation between galectin-3 levels and metformin concentration was either absent or weak after adjusting for the daily dose, indicating that treatment duration and dosage, rather than absolute drug levels, may more critically influence galectin-3. This study offers deeper insights into the role of personalized metformin dosing in managing PCOS, enhancing the understanding of metabolic and hormonal regulation in this condition, and laying the groundwork for future targeted therapies. |
| format | Article |
| id | doaj-art-f8efa403a25b43c6848fe0e2a8e212bb |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-f8efa403a25b43c6848fe0e2a8e212bb2025-01-31T06:40:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15050221505022Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVFValentina N. Nikolić0Milan Stefanović1Milan Stefanović2Dejan Mitić3Dejan Mitić4Slavica Sunarić5Vladana Stojiljkovic6Hristina Trajković7Aleksandra Ignjatović8Dragana Stokanović9Department of Pharmacology with Toxicology, University of Nis Faculty of Medicine, Niš, SerbiaDepartment of Gynaecology and Obstetrics, University of Nis Faculty of Medicine, Niš, SerbiaGynaecology and Obstetrics Clinic, University Clinical Centre Niš, Niš, SerbiaDepartment of Gynaecology and Obstetrics, University of Nis Faculty of Medicine, Niš, SerbiaGynaecology and Obstetrics Clinic, University Clinical Centre Niš, Niš, SerbiaDepartment of Chemistry, University of Niš Faculty of Medicine, Niš, SerbiaDepartment of Biochemistry, Medical Faculty University of Niš, University Clinical Center Niš, Niš, SerbiaDepartment of Pharmacology with Toxicology, University of Nis Faculty of Medicine, Niš, SerbiaDepartment of Medical Statistics and Informatics, University of Nis Faculty of Medicine, Niš, SerbiaDepartment of Pharmacology with Toxicology, University of Nis Faculty of Medicine, Niš, SerbiaThis study explores the impact of metformin dosage and hyperprolactinemia on galectin-3 levels in women with Polycystic Ovary Syndrome (PCOS), providing novel insights into their roles in the metabolic and hormonal management of the condition. A cohort of 53 women, diagnosed using the Rotterdam criteria and undergoing in vitro fertilization (IVF) preparation, was analyzed to determine how these factors influence galectin-3, a biomarker in PCOS. Using high-performance liquid chromatography to measure metformin concentrations and ELISA for galectin-3, our results revealed that both metformin dosage and hyperprolactinemia significantly statistically associated with galectin-3 levels, while body mass index (BMI) showed no significant association. These findings challenge prior assumptions and suggest that galectin-3 may be regulated via pathways independent of metformin pharmacokinetics. Notably, the correlation between galectin-3 levels and metformin concentration was either absent or weak after adjusting for the daily dose, indicating that treatment duration and dosage, rather than absolute drug levels, may more critically influence galectin-3. This study offers deeper insights into the role of personalized metformin dosing in managing PCOS, enhancing the understanding of metabolic and hormonal regulation in this condition, and laying the groundwork for future targeted therapies.https://www.frontiersin.org/articles/10.3389/fphar.2024.1505022/fullpolycystic ovary syndrome (PCOS)galectin-3metforminhyperprolactinemiabody mass indexmetabolic pathways |
| spellingShingle | Valentina N. Nikolić Milan Stefanović Milan Stefanović Dejan Mitić Dejan Mitić Slavica Sunarić Vladana Stojiljkovic Hristina Trajković Aleksandra Ignjatović Dragana Stokanović Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF Frontiers in Pharmacology polycystic ovary syndrome (PCOS) galectin-3 metformin hyperprolactinemia body mass index metabolic pathways |
| title | Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF |
| title_full | Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF |
| title_fullStr | Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF |
| title_full_unstemmed | Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF |
| title_short | Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF |
| title_sort | metformin dosage and galectin 3 levels insights from pcos patients preparing for ivf |
| topic | polycystic ovary syndrome (PCOS) galectin-3 metformin hyperprolactinemia body mass index metabolic pathways |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1505022/full |
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