Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis
Introduction Non-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Currently, surgical resection is the gold standard of treatment. However, as patients are becoming medically more complex presenting with advanced disease, minimally invasive image-guided percutaneous ablatio...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e057638.full |
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| author | Arun Chockalingam Menelaos Konstantinidis Brandon Koo John Timothy Moon Andrew Tran Sahar Nourouzpour Emily Lawson Kathleen Fox Peiman Habibollahi Bruno Odisio Mohammed Loya Ali Bassir Nariman Nezami |
| author_facet | Arun Chockalingam Menelaos Konstantinidis Brandon Koo John Timothy Moon Andrew Tran Sahar Nourouzpour Emily Lawson Kathleen Fox Peiman Habibollahi Bruno Odisio Mohammed Loya Ali Bassir Nariman Nezami |
| author_sort | Arun Chockalingam |
| collection | DOAJ |
| description | Introduction Non-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Currently, surgical resection is the gold standard of treatment. However, as patients are becoming medically more complex presenting with advanced disease, minimally invasive image-guided percutaneous ablations are gaining popularity. Therefore, comparison of surgical, ablative and second-line external beam therapies will help clinicians, as management of NSCLC changes. We will conduct a meta-analysis, reviewing literature investigating these therapies in adult patients diagnosed with stage 1 NSCLC, with neither hilar nor mediastinal nodal involvement, confirmed either through cytology or histology regardless of type.Methods and analysis We will search electronic databases (MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, Cochrane) from their inception to January 2021 to identify randomised controlled trials (RCTs), cluster RCTs and cohort studies comparing survival and clinical outcomes between any two interventions (lobectomy, wedge resection, video-assisted thoracoscopic surgery/robot-assisted thoracoscopic surgery, radiofrequency ablation, microwave ablation, cryoablation and consolidated radiation therapies (external beam radiation therapy, stereotactic body radiation therapy, and 3D conformal radiation therapy). The primary outcomes will include cancer-specific survival, lung disease-free survival, locoregional recurrence, death, toxicity and non-target organ injury. We will also search published and unpublished studies in trial registries and will review references of included studies for possible inclusion. Risk of bias will be assessed using tools developed by the Cochrane collaboration. Two reviewers will independently assess the eligibility of studies and conduct the corresponding risk of bias assessments. For each outcome, given enough studies, we will conduct a network meta-analysis. Finally, we will use the Confidence in Network Meta-Analysis tool to assess quality of the evidence for each of the primary outcomes.Ethics and dissemination We aim to share our findings through high-impact peer review. As interventional techniques become more popular, it will be important for providers in multidisciplinary teams caring for these patients to receive continuing medical education related to these interventions. Data will be made available to readers.PROSPERO registration number CRD42021276629. |
| format | Article |
| id | doaj-art-f8a7c31bd084446aab6c18bc8b4bc0a0 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-f8a7c31bd084446aab6c18bc8b4bc0a02025-01-24T04:45:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-057638Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysisArun Chockalingam0Menelaos Konstantinidis1Brandon Koo2John Timothy Moon3Andrew Tran4Sahar Nourouzpour5Emily Lawson6Kathleen Fox7Peiman Habibollahi8Bruno Odisio9Mohammed Loya10Ali Bassir11Nariman Nezami12Harvard Medical School, Boston, Massachusetts, USAChild Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, CanadaBrown University, Providence, Rhode Island, USADepartment of Radiology and Imaging Sciences, Division of Interventional Radiology, Emory University School of Medicine, Atlanta, Georgia, USADepartment of Radiology and Imaging Sciences, Division of Interventional Radiology, Emory University School of Medicine, Atlanta, Georgia, USAUniversity Health Network, Toronto, Ontario, CanadaWoodruff Health Sciences Center Library, Emory University Woodruff Health Sciences Center, Atlanta, Georgia, USAWoodruff Health Sciences Center Library, Emory University Woodruff Health Sciences Center, Atlanta, Georgia, USADepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Radiology and Imaging Sciences, Division of Interventional Radiology, Emory University School of Medicine, Atlanta, Georgia, USAUniversity of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USADivision of Vascular and Interventional Radiology, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USAIntroduction Non-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Currently, surgical resection is the gold standard of treatment. However, as patients are becoming medically more complex presenting with advanced disease, minimally invasive image-guided percutaneous ablations are gaining popularity. Therefore, comparison of surgical, ablative and second-line external beam therapies will help clinicians, as management of NSCLC changes. We will conduct a meta-analysis, reviewing literature investigating these therapies in adult patients diagnosed with stage 1 NSCLC, with neither hilar nor mediastinal nodal involvement, confirmed either through cytology or histology regardless of type.Methods and analysis We will search electronic databases (MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, Cochrane) from their inception to January 2021 to identify randomised controlled trials (RCTs), cluster RCTs and cohort studies comparing survival and clinical outcomes between any two interventions (lobectomy, wedge resection, video-assisted thoracoscopic surgery/robot-assisted thoracoscopic surgery, radiofrequency ablation, microwave ablation, cryoablation and consolidated radiation therapies (external beam radiation therapy, stereotactic body radiation therapy, and 3D conformal radiation therapy). The primary outcomes will include cancer-specific survival, lung disease-free survival, locoregional recurrence, death, toxicity and non-target organ injury. We will also search published and unpublished studies in trial registries and will review references of included studies for possible inclusion. Risk of bias will be assessed using tools developed by the Cochrane collaboration. Two reviewers will independently assess the eligibility of studies and conduct the corresponding risk of bias assessments. For each outcome, given enough studies, we will conduct a network meta-analysis. Finally, we will use the Confidence in Network Meta-Analysis tool to assess quality of the evidence for each of the primary outcomes.Ethics and dissemination We aim to share our findings through high-impact peer review. As interventional techniques become more popular, it will be important for providers in multidisciplinary teams caring for these patients to receive continuing medical education related to these interventions. Data will be made available to readers.PROSPERO registration number CRD42021276629.https://bmjopen.bmj.com/content/12/6/e057638.full |
| spellingShingle | Arun Chockalingam Menelaos Konstantinidis Brandon Koo John Timothy Moon Andrew Tran Sahar Nourouzpour Emily Lawson Kathleen Fox Peiman Habibollahi Bruno Odisio Mohammed Loya Ali Bassir Nariman Nezami Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis BMJ Open |
| title | Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis |
| title_full | Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis |
| title_fullStr | Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis |
| title_full_unstemmed | Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis |
| title_short | Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis |
| title_sort | surgical resection radiotherapy and percutaneous thermal ablation for treatment of stage 1 non small cell lung cancer protocol for a systematic review and network meta analysis |
| url | https://bmjopen.bmj.com/content/12/6/e057638.full |
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