Longitudinal Tracking of ALK-Rearranged NSCLC From Plasma Using Circulating Tumor RNA and Circulating Tumor DNA

Longitudinal Tracking of ALK-Rearranged NSCLC From Plasma Using Circulating Tumor RNA and Circulating Tumor DNA

Background: Although the administration of tyrosine-kinase inhibitors in ALK-rearranged NSCLC has revolutionized precision medicine, the detection of gene rearrangements from liquid biopsies remains challenging. RNA-based detection has revealed promising sensitivity for rearrangement detection and t...

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Main Authors: Simon Heeke, PhD, Saumil Gandhi, MD, PhD, Hai T. Tran, PharmD, Vincent K. Lam, MD, Lauren A. Byers, MD, Don L. Gibbons, MD, PhD, Carl M. Gay, MD, PhD, Mehmet Altan, MD, Mara B. Antonoff, MD, FACS, Xiuning Le, MD, PhD, Janet Tu, MD, Maliazurina B. Saad, PhD, Michelle Pek, PhD, Jonathan Poh, PhD, Kao Chin Ngeow, DPhil, Anne Tsao, MD, MBA, FACHE, Tina Cascone, MD, PhD, Marcelo V. Negrao, MD, Jia Wu, PhD, George R. Blumenschein, Jr., MD, John V. Heymach, MD, PhD, Yasir Y. Elamin, MD
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:JTO Clinical and Research Reports
Subjects:
ALK
NSCLC
Liquid biopsy
ctRNA
ctDNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364325000116
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