Hypocalcaemic cardiomyopathy: a description of two cases and a literature review
Abstract Hypocalcaemic cardiomyopathy is a rare form of dilated cardiomyopathy. The authors here present two cases in which symptomatic dilated cardiomyopathy was the result of severe hypocalcaemia. First, we report about a 26‐year‐old woman with primary hypoparathyroidism and then about a 74‐year‐o...
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Wiley
2020-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12693 |
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| author | Martin Válek Lenka Roblová Ivan Raška Jr. Dita Schaffelhoferová Tomáš Paleček |
| author_facet | Martin Válek Lenka Roblová Ivan Raška Jr. Dita Schaffelhoferová Tomáš Paleček |
| author_sort | Martin Válek |
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| description | Abstract Hypocalcaemic cardiomyopathy is a rare form of dilated cardiomyopathy. The authors here present two cases in which symptomatic dilated cardiomyopathy was the result of severe hypocalcaemia. First, we report about a 26‐year‐old woman with primary hypoparathyroidism and then about a 74‐year‐old man with secondary hypoparathyroidism following a thyroidectomy. In both cases, the left ventricular systolic function improved after calcium supplementation. In the first case, a lack of compliance led to a repeated decrease of both serum calcium level and left ventricular systolic function. The authors also present a comprehensive summary of all cases of hypocalcaemic dilated cardiomyopathy that have been described in literature to date. The mean age of the affected patients was 48.3 years, of which 62% were female patients. The most common causes of hypocalcaemic cardiomyopathy are primary hypoparathyroidism (50%) and post‐thyroidectomy hypoparathyroidism (26%). In the post‐thyroidectomy subgroup, the median time for the development of hypocalcaemic cardiomyopathy is 10 years (range: 1.5 months to 36 years). Hypocalcaemic cardiomyopathy leads to heart failure with reduced ejection fraction in 87% of patients. Generally, the most common complications of hypoparathyroidism and/or hypocalcaemia are cerebral calcifications, cognitive deficit, and cataracts. Once calcium supplementation is administered, the disease has a good prognosis and, in most individuals, a significant improvement (21%) or even normalization (74%) of the left ventricular systolic function occurs. |
| format | Article |
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| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
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| spelling | doaj-art-f81bd09127064b26b59bfd2e76c408e52025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731291130110.1002/ehf2.12693Hypocalcaemic cardiomyopathy: a description of two cases and a literature reviewMartin Válek0Lenka Roblová1Ivan Raška Jr.2Dita Schaffelhoferová3Tomáš Paleček4Second Department of Medicine, Department of Cardiovascular Medicine, General University Hospital in Prague and First Faculty of Medicine Charles University Prague Czech RepublicSecond Department of Medicine, Department of Cardiovascular Medicine, General University Hospital in Prague and First Faculty of Medicine Charles University Prague Czech RepublicThird Department of Medicine, Department of Endocrinology and Metabolism, General University Hospital in Prague and First Faculty of Medicine Charles University Prague Czech RepublicDepartment of Cardiology, Heart Center České Budějovice Hospital České Budějovice Czech RepublicSecond Department of Medicine, Department of Cardiovascular Medicine, General University Hospital in Prague and First Faculty of Medicine Charles University Prague Czech RepublicAbstract Hypocalcaemic cardiomyopathy is a rare form of dilated cardiomyopathy. The authors here present two cases in which symptomatic dilated cardiomyopathy was the result of severe hypocalcaemia. First, we report about a 26‐year‐old woman with primary hypoparathyroidism and then about a 74‐year‐old man with secondary hypoparathyroidism following a thyroidectomy. In both cases, the left ventricular systolic function improved after calcium supplementation. In the first case, a lack of compliance led to a repeated decrease of both serum calcium level and left ventricular systolic function. The authors also present a comprehensive summary of all cases of hypocalcaemic dilated cardiomyopathy that have been described in literature to date. The mean age of the affected patients was 48.3 years, of which 62% were female patients. The most common causes of hypocalcaemic cardiomyopathy are primary hypoparathyroidism (50%) and post‐thyroidectomy hypoparathyroidism (26%). In the post‐thyroidectomy subgroup, the median time for the development of hypocalcaemic cardiomyopathy is 10 years (range: 1.5 months to 36 years). Hypocalcaemic cardiomyopathy leads to heart failure with reduced ejection fraction in 87% of patients. Generally, the most common complications of hypoparathyroidism and/or hypocalcaemia are cerebral calcifications, cognitive deficit, and cataracts. Once calcium supplementation is administered, the disease has a good prognosis and, in most individuals, a significant improvement (21%) or even normalization (74%) of the left ventricular systolic function occurs.https://doi.org/10.1002/ehf2.12693Dilated cardiomyopathyHypocalcaemiaCalciumParathormoneHypoparathyroidismHeart failure |
| spellingShingle | Martin Válek Lenka Roblová Ivan Raška Jr. Dita Schaffelhoferová Tomáš Paleček Hypocalcaemic cardiomyopathy: a description of two cases and a literature review ESC Heart Failure Dilated cardiomyopathy Hypocalcaemia Calcium Parathormone Hypoparathyroidism Heart failure |
| title | Hypocalcaemic cardiomyopathy: a description of two cases and a literature review |
| title_full | Hypocalcaemic cardiomyopathy: a description of two cases and a literature review |
| title_fullStr | Hypocalcaemic cardiomyopathy: a description of two cases and a literature review |
| title_full_unstemmed | Hypocalcaemic cardiomyopathy: a description of two cases and a literature review |
| title_short | Hypocalcaemic cardiomyopathy: a description of two cases and a literature review |
| title_sort | hypocalcaemic cardiomyopathy a description of two cases and a literature review |
| topic | Dilated cardiomyopathy Hypocalcaemia Calcium Parathormone Hypoparathyroidism Heart failure |
| url | https://doi.org/10.1002/ehf2.12693 |
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