Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit

Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit

Abstract Alzheimer’s disease (AD) diagnosis relies on cerebrospinal fluid (CSF) biomarkers or amyloid PET. Alternatives for AD diagnosis from blood samples are needed to develop a fully-automated early-diagnosis approach, potentially implemented in a cognitive disorder unit. Plasma p-Tau217 was dete...

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Bibliographic Details
Main Authors: Lourdes Álvarez-Sánchez, Carmen Peña-Bautista, Laura Ferré-González, Ángel Balaguer, Julián Luis Amengual, Miguel Baquero, Consuelo Cháfer-Pericás
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Alzheimer disease
Biomarkers
Plasma
Diagnosis
Predictive model
Validation
Online Access:https://doi.org/10.1038/s41598-025-01511-3
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