SIRT1 antisense long noncoding RNA attenuates interleukin-1β-induced osteoarthritic gene expression in human chondrocytes through its mRNA interaction

SIRT1 antisense long noncoding RNA attenuates interleukin-1β-induced osteoarthritic gene expression in human chondrocytes through its mRNA interaction

Abstract Recent studies demonstrated the role of antisense long noncoding RNAs (AS lncRNAs) in regulating gene expression at the transcriptional or translational level. In this study, we assessed the effects of sirtuin 1 (SIRT1) AS lncRNA overexpression and inhibition, along with overexpression of m...

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Bibliographic Details
Main Authors: Takeo Tokura, Takehiko Matsushita, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SIRT1 antisense long-noncoding RNA
SIRT1
Chondrocytes
IL-1β
Osteoarthritis
Online Access:https://doi.org/10.1038/s41598-025-06565-x
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https://doi.org/10.1038/s41598-025-06565-x

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