The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K
This study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its solubility mechanisms for pharmaceutical formulation. W...
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Elsevier
2025-04-01
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| Series: | South African Journal of Chemical Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1026918525000071 |
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| author | Adel Noubigh Abdalazeem A. Omar Manef Abderrabba |
| author_facet | Adel Noubigh Abdalazeem A. Omar Manef Abderrabba |
| author_sort | Adel Noubigh |
| collection | DOAJ |
| description | This study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its solubility mechanisms for pharmaceutical formulation. We employed the inverse Kirkwood-Buff integrals (IKBI) method to extract key parameters from the solution thermodynamic properties of MET.HCl, yielding valuable insights into its behavior. The findings reveal that MET.HCl is sensitive to solvation effects, with the values of δx1,MET-HCl exhibiting a non-linear relationship with the proportion of solvent (1) in the two solvent mixtures. Specifically, in both the methyl alcohol/water and ethyl alcohol/water systems, all alcoholic aqueous mixture compositions exhibit negative δx1,MET-HCl values. Overall, our results reveal that MET-HCl exhibits preferential solvation by water, with a significantly greater magnitude of preferential solvation observed in ethyl alcohol /water mixtures compared to methyl alcohol /water mixtures. This enhanced solvation by water may be attributed to the disordered structure of the alcohol molecules surrounding the polar regions of MET-HCl. The influence of solvent composition on the molar fraction solubility of MET-HCl was investigated using the Kamlet-Taft linear solvation energy relationship model. The KAT-LSER model revealed that solvent polarity (π*) and ability to accept hydrogen bonds (α) were key factors in MET-HCl dissolution in methyl alcohol and water, as well as ethyl alcohol and water. |
| format | Article |
| id | doaj-art-f805dd1b16f84890b6c8efc6f4f027cf |
| institution | Kabale University |
| issn | 1026-9185 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | South African Journal of Chemical Engineering |
| spelling | doaj-art-f805dd1b16f84890b6c8efc6f4f027cf2025-01-29T05:00:01ZengElsevierSouth African Journal of Chemical Engineering1026-91852025-04-0152104110The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 KAdel Noubigh0Abdalazeem A. Omar1Manef Abderrabba2Center for Scientific Research and Entrepreneurship, Northern Border University, 73213, Arar, Saudi Arabia; Corresponding author.Department of basic science, Deanship of Preparatory Year and Supporting studies, Imam Abdulrahman Bin Faisal University P.O. Box 1982, Dammam, Saudi ArabiaUniversité de Carthage, Institut Préparatoire aux Etudes Scientifiques et Techniques 99/UR/1201 unité de recherches de physico – chimie moléculaire, 2070, La Marsa, TunisieThis study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its solubility mechanisms for pharmaceutical formulation. We employed the inverse Kirkwood-Buff integrals (IKBI) method to extract key parameters from the solution thermodynamic properties of MET.HCl, yielding valuable insights into its behavior. The findings reveal that MET.HCl is sensitive to solvation effects, with the values of δx1,MET-HCl exhibiting a non-linear relationship with the proportion of solvent (1) in the two solvent mixtures. Specifically, in both the methyl alcohol/water and ethyl alcohol/water systems, all alcoholic aqueous mixture compositions exhibit negative δx1,MET-HCl values. Overall, our results reveal that MET-HCl exhibits preferential solvation by water, with a significantly greater magnitude of preferential solvation observed in ethyl alcohol /water mixtures compared to methyl alcohol /water mixtures. This enhanced solvation by water may be attributed to the disordered structure of the alcohol molecules surrounding the polar regions of MET-HCl. The influence of solvent composition on the molar fraction solubility of MET-HCl was investigated using the Kamlet-Taft linear solvation energy relationship model. The KAT-LSER model revealed that solvent polarity (π*) and ability to accept hydrogen bonds (α) were key factors in MET-HCl dissolution in methyl alcohol and water, as well as ethyl alcohol and water.http://www.sciencedirect.com/science/article/pii/S1026918525000071Metformin hydrochlorideBinary solventsSolvent effectIKBI methodPreferential solvation |
| spellingShingle | Adel Noubigh Abdalazeem A. Omar Manef Abderrabba The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K South African Journal of Chemical Engineering Metformin hydrochloride Binary solvents Solvent effect IKBI method Preferential solvation |
| title | The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K |
| title_full | The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K |
| title_fullStr | The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K |
| title_full_unstemmed | The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K |
| title_short | The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K |
| title_sort | solvent effect preferential solvation of metformin hydrochloride in binary mixed solvents of methanol ethanol water mixtures from 278 15 k to 323 15 k |
| topic | Metformin hydrochloride Binary solvents Solvent effect IKBI method Preferential solvation |
| url | http://www.sciencedirect.com/science/article/pii/S1026918525000071 |
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